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Cat. No.: HY-144648

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Mpro/PLpro-IN-1

Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of M^pro/PL^pro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus M^pro (IC₅₀ = 1.72 μM) and submicromolar potency versus PL^pro (IC₅₀ = 0.67 μM).

For research use only. We do not sell to patients.

CAS No.: 2766185-78-6
Formula: C₂₅H₂₇ClN₄O₃
Molecular Weight:466.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Mpro/PLpro-IN-1 Chemical Structure

CAS No.: 2766185-78-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	>50 μM Compound: CV11	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter method Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth by coulter counter method	[PMID: 38232463]
Vero	CC₅₀	38.67 μM Compound: 29	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by coulter counter method	[PMID: 34571172]
Vero	EC₅₀	1.37 μM Compound: 29	Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis Antiviral activity against Severe acute respiratory syndrome coronavirus 2 UC-1075 infected in African green monkey Vero cells assessed as reduction in plaque formation measured after 5 days by microscopic analysis	[PMID: 34571172]

Chemical Information

CAS No. 2766185-78-6
Molecular Weight 466.96
Formula C₂₅H₂₇ClN₄O₃
SMILES

C=CC[C@H](NC(CCl)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCC3=CC=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Di Sarno V, et al. Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization. Eur J Med Chem. 2021;226:113863. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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