2. GPCR/G Protein
  3. Adenosine Receptor Arrestin
  4. MRS542

MRS542 is a nucleoside A3 AR antagonist with a pKi of 8.74. MRS542 also acts as a partial agonist (pEC50 = 7.76) in promoting β-arrestin translocation. MRS542 can be converted into an agonist by LUF6000 (HY-13236). MRS542 can be used for cardiovascular disease research.

For research use only. We do not sell to patients.

MRS542

MRS542 Chemical Structure

CAS No. : 163152-31-6

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MRS542 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Arrestin-2/β-Arrestin 1 Arrestin-3/β-Arrestin 2

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Description

MRS542 is a nucleoside A3 AR antagonist with a pKi of 8.74. MRS542 also acts as a partial agonist (pEC50 = 7.76) in promoting β-arrestin translocation. MRS542 can be converted into an agonist by LUF6000 (HY-13236). MRS542 can be used for cardiovascular disease research[1][2].

IC50 & Target[2]

A3

8.76 (pKi)

Molecular Weight

517.71

Formula

C17H17ClIN5O4
CAS No.
SMILES

N(CC1=CC(I)=CC=C1)C2=C3C(N(C=N3)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)=NC(Cl)=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRS542 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS542163152-31-6MRS 542MRS-542Adenosine ReceptorArrestinP1 receptorβ-arrestin translocationLUF6000cardiovascular diseaseInhibitorinhibitorinhibit

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