2. Immunology/Inflammation Apoptosis
  3. CD20 Apoptosis
  4. MT-3724

MT-3724 is a CD20-targeted endotoxin B. MT-3724 binds to CD20, triggers receptor internalization, traffics to the endoplasmic reticulum, and induces permanent ribosomal inactivation to mediate cell killing. MT-3724 can inhibit protein synthesis and promote tumor cell apoptosis. MT-3724 can be used for the research of relapsed or refractory B-cell non-Hodgkin’s lymphomas and diffuse large B-cell lymphoma.

For research use only. We do not sell to patients.

MT-3724

MT-3724 Chemical Structure

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MT-3724 Related Antibodies

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Description

MT-3724 is a CD20-targeted endotoxin B. MT-3724 binds to CD20, triggers receptor internalization, traffics to the endoplasmic reticulum, and induces permanent ribosomal inactivation to mediate cell killing. MT-3724 can inhibit protein synthesis and promote tumor cell apoptosis. MT-3724 can be used for the research of relapsed or refractory B-cell non-Hodgkin’s lymphomas and diffuse large B-cell lymphoma[1][2].

Species Reactivity

Human
In Vitro

MT-3724 specifically targets and directly kills CD20+ cells via permanent ribosomal inactivation[1].
MT-3724‘s Shiga toxin A subunit inhibits protein synthesis and promotes apoptosis of tumor cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MT-3724 Related Antibodies
In Vivo

MT-3724 reduces tumor growth in a Daudi-Luc xenograft murine model of B-cell non-Hodgkin's lymphoma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

931  [NCBI]

Accession
Target

CD20/MS4A1
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MT-3724 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-3724MT3724MT 3724CD20ApoptosisShiga-like Toxin A subunitendoplasmic reticulumribosome-inactivating activityDaudi-Luc xenograft murine modelB-cell non-Hodgkin’s lymphomasdiffuse large B-cell lymphomaCD20+ cellsShiga-like Toxin B subunitInhibitorinhibitorinhibit

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MT-3724
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