Mukurozioside IIb
Mukurozioside IIb is a sesquiterpene glycoside found in S. mukorossi and Sapindus rarak. Mukurozioside IIb can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 103001-34-9
- Formula: C51H86O28
- Molecular Weight:1147.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mukurozioside IIb (200 μg/mL) moderately inhibits the proliferation of MCF-7, MDA-MB-231, and MDA-MB-435s human breast cancer cells in vitro, with an approximate 80% inhibition rate at 200 μg/mL and no significant differences in IC50 values across the three cell lines[1].
Mukurozioside IIb (3-100 μM; 44 h) shows no significant inhibitory effect on TNF-α-induced cytotoxicity in L929 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L929 cells
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Concentration:3 μM; 10 μM; 30 μM; 100 μM
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Incubation Time:44 h
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Result:Showed 1% inhibition of TNF-α-induced cytotoxicity at 3 μM.
Showed -10% inhibition of TNF-α-induced cytotoxicity at 10 μM.
Showed -4% inhibition of TNF-α-induced cytotoxicity at 30 μM.
Showed -11% inhibition of TNF-α-induced cytotoxicity at 100 μM.
Demonstrated no statistically significant effects relative to the control.
Chemical Information
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CAS No. 103001-34-9
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Molecular Weight 1147.21
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Formula C51H86O28
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SMILES
O[C@H]([C@@H]([C@H]([C@@H](O1)C)O)O)[C@@H]1O[C@@H]([C@@H]([C@H](O[C@H]2OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CO[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)CO)O)[C@H]2O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)O)O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wei MP, et al. Isolation of two sesquiterpene glycosides from Sapindus mukorossi Gaertn. with cytotoxic properties and analysis of their mechanism based on network pharmacology. Nat Prod Res. 2021 Nov;35(22):4323-4330. [Content Brief]
[2]. Morikawa T, et al. Inhibitory effects of acylated acyclic sesquiterpene oligoglycosides from the pericarps of Sapindus rarak on tumor necrosis factor-alpha-induced cytotoxicity. Chem Pharm Bull (Tokyo). 2010;58(9):1276-1280. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mukurozioside IIb Related Classifications
HY-N19872 Related Classifications
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