Complement Factor B
Complement factor B is the zymogen that powers the alternative pathway. Circulating as a single chain, it binds C3b in a Mg2+-dependent manner through its von Willebrand factor type A domain; factor D then cleaves it into the Ba fragment and the active Bb serine protease, and C3bBb constitutes the alternative-pathway C3 convertase. Its three CCP domains and C-terminal protease domain closely parallel the classical-pathway protease C2, reflecting their shared ancestry within the MHC class III region. Genetic variants of factor B influence susceptibility to age-related macular degeneration. Recombinant factor B enables reconstitution of alternative-pathway assays.
-
Complement Factor B Recombinant Proteins (3)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
