N1-Methylpseudouridine-5′-triphosphate (Synonyms: 1-Methylpseudouridine-5′-triphosphate)

Cat. No.: HY-112582A: FAQs
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N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (N1-Methylpseudouridine-5′-triphosphate trisodium) that retains the same biological activity.

For research use only. We do not sell to patients.

N1-Methylpseudouridine-5′-triphosphate Chemical Structure

CAS No. : 1428903-59-6

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Other In-stock Forms of N1-Methylpseudouridine-5′-triphosphate:

N1-Methylpseudouridine N1-Methylpseudouridine-5′-triphosphate trisodium

Other Forms of N1-Methylpseudouridine-5′-triphosphate:

N1-Methylpseudouridine In-stock
N1-Methylpseudouridine-5′-triphosphate trisodium In-stock
N1-Methylpseudouridine-5′-triphosphate tetralithium Get quote

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Description	N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
Molecular Weight	498.17
Formula	C₁₀H₁₇N₂O₁₅P₃
CAS No.	1428903-59-6
SMILES	O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(C)C2=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344. [Content Brief]

N1-Methylpseudouridine-5′-triphosphate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N1-Methylpseudouridine-5′-triphosphate1428903-59-61-Methylpseudouridine-5′-triphosphateNucleoside Antimetabolite/AnalogDNA/RNA Synthesisnucleobase-modified nucleotidemRNAInhibitorinhibitorinhibit

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N1-Methylpseudouridine-5′-triphosphate (Synonyms: 1-Methylpseudouridine-5′-triphosphate)

Other Forms of N1-Methylpseudouridine-5′-triphosphate:

N1-Methylpseudouridine-5′-triphosphate Related Antibodies

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