N1-Methylpseudouridine-5′-triphosphate trisodium solution (100 mM)
Based on 1 publication(s) in Google Scholar
N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium solution (100 mM) is a nucleobase-modified nucleotide. N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium solution (100 mM) is used for synthesizing mRNA with reduced immunogenicity and improved stability.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 3056945-59-3
- Formula: C10H14N2Na3O15P3
- Molecular Weight:564.11
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Storage:
-80°C
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) N1-Methylpseudouridine-5′-triphosphate trisodium solution (100 mM)
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
N1-Methylpseudouridine-5′-triphosphate trisodium solution (100 mM) is used to synthesize mRNAs with lower immunogenicity and higher stability[1].
Modified mRNAs synthesized from N1-Methylpseudouridine-5′-triphosphate trisodium solution (100 mM) can be delivered to the heart[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3056945-59-3
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Appearance Liquid
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Molecular Weight 564.11
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Formula C10H14N2Na3O15P3
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Color Colorless to light yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(C)C2=O)O[C@@H]1COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
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Synonyms
1-Methylpseudouridine-5′-triphosphate trisodium; N1-Me-Pseudo UTP trisodium; N1-Methyl-Pseudo-UTP trisodium
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Shipping
Shipping with dry ice.
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Storage
-80°C
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
H2O : 100 mg/mL (177.27 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344. [Content Brief]
[2]. Sultana N, et al. Optimizing Cardiac Delivery of Modified mRNA. Mol Ther. 2017 Jun 7;25(6):1306-1315. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7727 mL | 8.8635 mL | 17.7270 mL | 44.3176 mL |
| 5 mM | 0.3545 mL | 1.7727 mL | 3.5454 mL | 8.8635 mL | |
| 10 mM | 0.1773 mL | 0.8864 mL | 1.7727 mL | 4.4318 mL | |
| 15 mM | 0.1182 mL | 0.5909 mL | 1.1818 mL | 2.9545 mL | |
| 20 mM | 0.0886 mL | 0.4432 mL | 0.8864 mL | 2.2159 mL | |
| 25 mM | 0.0709 mL | 0.3545 mL | 0.7091 mL | 1.7727 mL | |
| 30 mM | 0.0591 mL | 0.2955 mL | 0.5909 mL | 1.4773 mL | |
| 40 mM | 0.0443 mL | 0.2216 mL | 0.4432 mL | 1.1079 mL | |
| 50 mM | 0.0355 mL | 0.1773 mL | 0.3545 mL | 0.8864 mL | |
| 60 mM | 0.0295 mL | 0.1477 mL | 0.2955 mL | 0.7386 mL | |
| 80 mM | 0.0222 mL | 0.1108 mL | 0.2216 mL | 0.5540 mL | |
| 100 mM | 0.0177 mL | 0.0886 mL | 0.1773 mL | 0.4432 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N1-Methylpseudouridine-5′-triphosphate trisodium solution (100 mM) Related Classifications
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