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Art. -Nr.: HY-189740

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nAChR-IN-3

nAChR-IN-3 is an nAChR α6 subunit inhibitor and broad-spectrum insecticide against Acyrthosiphon pisum, Nilaparvata lugens, and Bemisia tabaci. nAChR-IN-3 acts through the nicotinic acetylcholine receptor α6 subunit; α6 silencing increases aphid tolerance and α6-null Drosophila show high-level resistance. nAChR-IN-3 disrupts ionic homeostasis and cholinergic signaling in nerve cells. nAChR-IN-3 induces mitochondrial electron transport chain disruption and reactive oxygen species burst. nAChR-IN-3 inhibits ATP synthesis and collapses energy metabolism. nAChR-IN-3 shows low toxicity to non-target honeybees, zebrafish, and earthworms and no inhibition of crop seed germination or seedling development. nAChR-IN-3 displays cytotoxicity in human keratinocytes and renal cells.

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CAS. Nr.: 3127776-54-6
Formel: C₁₈H₁₄ClN₅O₃
Molecular Weight:383.79

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

nAChR-IN-3 Chemical Structure

CAS. Nr.: 3127776-54-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

Oxidative StressOthers

Oxidative Stress

nAChR-IN-3 (6-24 h) induces time-dependent ROS accumulation in primary A. pisum cells, reaching 3.06 times that of the control at 24 h^[1].

Others

nAChR-IN-3 (compound Q1) (2.5-20 μM; 48 h) produces dose-dependent cytotoxicity in HaCAT, HK2, LX2, WPMY-1, and RHNC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human HaCAT keratinocytes, HK2 kidney cells, LX2 liver cells, WPMY-1 prostate cells, and rat RHNC hippocampal neuron cells
Concentration:

2.5, 5, 10, 20 μM
Incubation Time:

48 h
Result:

Produced dose-dependent cytotoxicity in HaCAT, HK2, LX2, WPMY-1, and RHNC cells, with HaCAT viability decreasing from 0.83 to 0.71 across 2.5-10 μM and HK2 viability of 0.57 at 10 μM.

In Vivo

nAChR-IN-3 (compound Q1) (200-600 mg/L; 24 h-7 days) does not inhibit rice seed germination or seedling growth, with the germination rate remaining above 95%^[1].
nAChR-IN-3 (0.390625-50 mg/L; artificial feeding; 48 h) exhibits broad-spectrum high insecticidal activity against B. tabaci populations, with LC₅₀ values ranging from 0.99 to 9.60 mg/L^[1].
nAChR-IN-3 (200 μL Q1 insecticidal solution; agar feeding; 48 h) produces a highly resistant phenotype in α6-silenced Acyrthosiphon pisum and over 690-fold resistance in α6-knockout Drosophila melanogaster mutants, confirming nAChR α6 as its key target of action^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 3127776-54-6
Molecular Weight 383.79
Formel C₁₈H₁₄ClN₅O₃
SMILES

ClC1=CC=C(CN2C=CC=C3C2=NC(N(C4=C(C)ON=C4C)C3=O)=O)C=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li Q, et al. Discovery of A Safe and Effective Hemipteran Insecticide: α6 nAChR‑Targeting Non‑Mesoionic Scaffold. Journal of Agricultural and Food Chemistry. 2026;74(37):29071‑29087.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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