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Cat. No.: HY-189023

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ND-L11A TFA

ND-L11A TFA is the R-configured enantiomer of the NSD2 degrader ND-L11, with K_D >100 μM. ND-L11A TFA fails to induce significant NSD2 protein degradation in multiple myeloma KMS11 cells and shows no significant antiproliferative effect on NSD2-driven KMS11 cells. ND-L11A TFA can be used in the study of multiple myeloma.

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CAS No.: 3078788-63-0
Formule: C₃₉H₅₂F₆N₁₀O₄
Masse moléculaire:838.89

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Please store the product under the recommended conditions in the Certificate of Analysis.

ND-L11A TFA Chemical Structure

CAS No.: 3078788-63-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

In Vitro

OthersAnti-cancer

Others

ND‑L11A TFA binds weakly to the NSD2 SET domain in SPR, with K_D >100 μM^[1].

Anti-cancer

ND‑L11A TFA does not induce NSD2 degradation in KMS11 multiple myeloma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 3078788-63-0
Masse moléculaire 838.89
Formule C₃₉H₅₂F₆N₁₀O₄
SMILES

OC(C(F)(F)F)=O.NCCCCCCCCCCCNC(COC(C=C1C2=NC=C(N3C[C@@](N)(CCC3)CC(F)F)C(CN4C5=NC=NC(N)=C5N=C4)=C2)=C(C=C1)F)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hu L, et al. Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms. European journal of medicinal chemistry. 2025 Feb 05;283:117179. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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