2. Anti-infection NF-κB
  3. Bacterial IKK
  4. NDM-622

NDM-622 is a Colistin (HY-113678) adjuvant. NDM-622 weakly inhibits IKKβ with an IC50 of 20.40 μM. NDM-622 reduces the minimum inhibitory concentration of colistin against colistin-highly-resistant Acinetobacter baumannii and Klebsiella pneumoniae. NDM-622 decreases bacterial colony-forming units in a mouse peritonitis model infected with colistin-highly-resistant Klebsiella pneumoniae. NDM-622 does not modify bacterial lipid A, induce reactive oxygen species production, or increase bacterial membrane permeability. NDM-622 can be used in the research of extensively drug-resistant Gram-negative bacterial infections, colistin-resistant Acinetobacter baumannii infections, and Klebsiella pneumoniae infections.

For research use only. We do not sell to patients.

NDM-622

NDM-622 Chemical Structure

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NDM-622 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

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Description

NDM-622 is a Colistin (HY-113678) adjuvant. NDM-622 weakly inhibits IKKβ with an IC50 of 20.40 μM. NDM-622 reduces the minimum inhibitory concentration of colistin against colistin-highly-resistant Acinetobacter baumannii and Klebsiella pneumoniae. NDM-622 decreases bacterial colony-forming units in a mouse peritonitis model infected with colistin-highly-resistant Klebsiella pneumoniae. NDM-622 does not modify bacterial lipid A, induce reactive oxygen species production, or increase bacterial membrane permeability. NDM-622 can be used in the research of extensively drug-resistant Gram-negative bacterial infections, colistin-resistant Acinetobacter baumannii infections, and Klebsiella pneumoniae infections[1].

IC50 & Target[1]

IKKβ

20.40 μM (IC50)

In Vitro

NDM-622 (2-10 μM; 16-20 h) potently enhances the activity of Colistin (HY-113678) against Colistin-resistant Acinetobacter baumannii AB4106 and Klebsiella pneumoniae KPB9, and reduces the MIC of Colistin by up to 4096-fold at a concentration of 10 μM[1].
NDM-622 (5 μM; 1 h) does not enhance the cell membrane permeability of colistin-resistant Acinetobacter baumannii AB4106; at a dose of 5 μM, it only causes a slight and statistically insignificant increase in the permeability of colistin-resistant Klebsiella pneumoniae KPB9[1].
NDM-622 (24 h) exhibits low toxicity against hepatocellular carcinoma cell line HepG2, with an IC50 value of 125 μM[1].
NDM-622 (pre-incubated for 30 min) weakly inhibits IκB kinase-β in HEK293-NFκB-Luc cells, with an IC50 of 20.40 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NDM-622 Related Antibodies
In Vivo

NDM-622 (50 mg/kg; i.p.; 3 doses) acts as an effective in vivo colistin adjuvant in a murine peritonitis model, producing a significant reduction in Klebsiella pneumoniae B9 CFUs when co-administered with colistin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 129S6/SvEvTac (male and female, 6-7 months old, cyclophosphamide-induced immunosuppression)[1]
Dosage: 50 mg/kg
Administration: i.p.; 3 doses (0.25 hours pre-inoculation, 1 hour post-inoculation, 2.5 hours post-inoculation)
Result: Produced a statistically significant reduction in Klebsiella pneumoniae B9 colony forming units (CFUs) recovered from the peritoneal cavity compared to control mice treated with colistin plus vehicle.
Molecular Weight

475.12

Formula

C15H8F6INO2
SMILES

O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C2=CC(O)=C(I)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NDM-622 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDM-622NDM622NDM 622BacterialIKKIκB kinaseI kappa B kinaseHepG2 human liver cancer cellsKlebsiella pneumoniaeliver cellsHEK293-NFκB-Luc cellsextensively drug-resistant gram-negative bacterial infectionsmurine peritonitis modelAcinetobacter baumanniiIκB kinase-βmcr-1-harboring isolatescolistin-resistant Acinetobacter baumannii infectionInhibitorinhibitorinhibit

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