NDM-622
NDM-622 is a Colistin (HY-113678) adjuvant. NDM-622 weakly inhibits IKKβ with an IC50 of 20.40 μM. NDM-622 reduces the minimum inhibitory concentration of colistin against colistin-highly-resistant Acinetobacter baumannii and Klebsiella pneumoniae. NDM-622 decreases bacterial colony-forming units in a mouse peritonitis model infected with colistin-highly-resistant Klebsiella pneumoniae. NDM-622 does not modify bacterial lipid A, induce reactive oxygen species production, or increase bacterial membrane permeability. NDM-622 can be used in the research of extensively drug-resistant Gram-negative bacterial infections, colistin-resistant Acinetobacter baumannii infections, and Klebsiella pneumoniae infections.
For research use only. We do not sell to patients.
- Formula: C15H8F6INO2
- Molecular Weight:475.12
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
IKKβ 20.40 μM (IC50) |
NDM-622 (2-10 μM; 16-20 h) potently enhances the activity of Colistin (HY-113678) against Colistin-resistant Acinetobacter baumannii AB4106 and Klebsiella pneumoniae KPB9, and reduces the MIC of Colistin by up to 4096-fold at a concentration of 10 μM[1].
NDM-622 (5 μM; 1 h) does not enhance the cell membrane permeability of colistin-resistant Acinetobacter baumannii AB4106; at a dose of 5 μM, it only causes a slight and statistically insignificant increase in the permeability of colistin-resistant Klebsiella pneumoniae KPB9[1].
NDM-622 (24 h) exhibits low toxicity against hepatocellular carcinoma cell line HepG2, with an IC50 value of 125 μM[1].
NDM-622 (pre-incubated for 30 min) weakly inhibits IκB kinase-β in HEK293-NFκB-Luc cells, with an IC50 of 20.40 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:129S6/SvEvTac (male and female, 6-7 months old, cyclophosphamide-induced immunosuppression)[1]
-
Dosage:50 mg/kg
-
Administration:i.p.; 3 doses (0.25 hours pre-inoculation, 1 hour post-inoculation, 2.5 hours post-inoculation)
-
Result:Produced a statistically significant reduction in Klebsiella pneumoniae B9 colony forming units (CFUs) recovered from the peritoneal cavity compared to control mice treated with colistin plus vehicle.
Chemical Information
-
Molecular Weight 475.12
-
Formula C15H8F6INO2
-
SMILES
O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C2=CC(O)=C(I)C=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NDM-622 Related Classifications
HY-184325 Related Classifications
Powered by Bioz
- NDM-622
- NDM622
- NDM 622
- Bacterial
- IKK
- HepG2 human liver cancer cells
- Klebsiella pneumoniae
- liver cells
- HEK293-NFκB-Luc cells
- extensively drug-resistant gram-negative bacterial infections
- murine peritonitis model
- Acinetobacter baumannii
- IκB kinase-β
- mcr-1-harboring isolates
- colistin-resistant Acinetobacter baumannii infection
- Inhibitor
- inhibitor
- inhibit