2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. NJH-2-030

NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications.

For research use only. We do not sell to patients.

NJH-2-030 Chemical Structure

NJH-2-030 Chemical Structure

CAS No. : 2709040-02-6

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 440 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1350 In-stock
50 mg USD 2200 In-stock
100 mg USD 3400 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

NJH-2-030 Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications.

Molecular Weight

373.83

Formula

C19H20ClN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C#CCCCC(N1CCOC2=C1C=CC(N(C(CCl)=O)CCC#N)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (66.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6750 mL 13.3751 mL 26.7501 mL
5 mM 0.5350 mL 2.6750 mL 5.3500 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.74%

COA (254 KB) HNMR (287 KB) LCMS (270 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6750 mL 13.3751 mL 26.7501 mL 66.8753 mL
5 mM 0.5350 mL 2.6750 mL 5.3500 mL 13.3751 mL
10 mM 0.2675 mL 1.3375 mL 2.6750 mL 6.6875 mL
15 mM 0.1783 mL 0.8917 mL 1.7833 mL 4.4584 mL
20 mM 0.1338 mL 0.6688 mL 1.3375 mL 3.3438 mL
25 mM 0.1070 mL 0.5350 mL 1.0700 mL 2.6750 mL
30 mM 0.0892 mL 0.4458 mL 0.8917 mL 2.2292 mL
40 mM 0.0669 mL 0.3344 mL 0.6688 mL 1.6719 mL
50 mM 0.0535 mL 0.2675 mL 0.5350 mL 1.3375 mL
60 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1146 mL
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NJH-2-030 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NJH-2-0302709040-02-6E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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