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Cat. No.: HY-189733

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NK037

NK037 is a phthalimide derivative that exhibits multi-target enzyme inhibitory activity against urease, xanthine oxidase, and butyrylcholinesterase (BChE). NK037 inhibits urease with IC₅₀ = 2.9 μM, xanthine oxidase with IC₅₀ = 5.61 μM, and butyrylcholinesterase with IC₅₀ = 9.49 μM. NK037 can form enzyme-ligand complexes with urease, xanthine oxidase, and thymidine phosphorylase. Urease-IN-26 can be used for metabolism-related research.

For research use only. We do not sell to patients.

CAS No.: 60945-03-1
Formula: C₁₅H₈N₂O₂S
Molecular Weight:280.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NK037 Chemical Structure

CAS No.: 60945-03-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

BChE

9.49 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

NK037 (compound C15) (0.156-5 mM) inhibits jack bean urease in the indophenol colorimetric assay with an IC₅₀ of 2.90 μM; inhibits Escherichia coli thymidine phosphorylase in the thymidine substrate assay with an IC₅₀ of 17.81 μM; inhibits bovine milk xanthine oxidase with an IC₅₀ of 5.61 μM; inhibits horse serum butyrylcholinesterase with an IC₅₀ of 9.49 μM^[1].
NK037 (1‑8 μM) can bind to jack bean urease, bovine milk xanthine oxidase, and Escherichia coli thymidine phosphorylase, with dissociation constants K_d of 0.04 μM, 0.12 μM, and 0.49 μM, respectively, and binding constants K_b of 26.97 μM^-1, 8.44 μM^-1, and 2.03 μM^-1, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 60945-03-1
Molecular Weight 280.30
Formula C₁₅H₈N₂O₂S
SMILES

O=C1N(C2=NC3=C(C=CC=C3)S2)C(C4=CC=CC=C41)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Khushal A, et al. Synthesis, multi-target enzyme inhibition, and in silico evaluation of phthalimide derivatives with relevance to tuberculosis-associated pathophysiology. Bioorganic chemistry. 2026 Aug 31;182:110441.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NK037

All Cholinesterase (ChE) Isoforms