Tween 80
Based on 111 publication(s) in Google Scholar
Tween 80 (Polysorbate 80), a surfactant, has been widely used as a solvent for pharmacological experiments. Tween 80 can also reduce bacterial attachment and inhibit biofilm formation.
For research use only. We do not sell to patients.
- CAS No.: 9005-65-6
- Formula: C64H124O26
- Molecular Weight:1309.63
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tween 80
More- Signal Transduct Target Ther. 2025 Dec 24;10(1):417. [Abstract]
- Signal Transduct Target Ther. 2023 Sep 25;8(1):366. [Abstract]
- Nature. 2026 May;653(8113):254-264. [Abstract]
- Cell. 2021 Sep 2;184(18):4753-4771.e27. [Abstract]
- Mol Cancer. 2024 Apr 27;23(1):85. [Abstract]
- Immunity. 2024 Mar 12;57(3):513-527.e6. [Abstract]
- Nat Metab. 2026 Jan;8(1):139-158. [Abstract]
- Cancer Res. 2021 Apr 1;81(7):1813-1826. [Abstract]
- Nat Commun. 2025 Oct 7;16(1):8906. [Abstract]
- Nat Commun. 2025 Jan 3;16(1):289. [Abstract]
- Nat Commun. 2023 May 24;14(1):2994. [Abstract]
- Nat Commun. 2023 May 19;14(1):2859. [Abstract]
- Acta Pharm Sin B. 2023 Jun;13(6):2680-2700. [Abstract]
- Adv Sci (Weinh). 2025 Apr 24:e2407671. [Abstract]
- Adv Sci (Weinh). 2024 Jul;11(26):e2306348. [Abstract]
- Nat Chem Biol. 2025 Sep 15. [Abstract]
- J Clin Invest. 2024 Jun 17;134(12):e177172. [Abstract]
- Theranostics. 2024 Aug 26;14(14):5429-5442. [Abstract]
- Theranostics. 2024 May 13;14(8):3029-3042. [Abstract]
- Chem Eng J. 2025 Oct 15.
- J Exp Clin Cancer Res. 2025 Jul 2;44(1):181. [Abstract]
- Sci Adv. 2025 Sep 26;11(39):eadq7665. [Abstract]
- Sci Adv. 2025 Aug 15;11(33):eadx6587. [Abstract]
- Int J Oral Sci. 2024 Jun 18;16(1):46. [Abstract]
- Redox Biol. 2025 Dec:88:103939. [Abstract]
- Biomark Res. 2023 Jan 24;11(1):8. [Abstract]
- Clin Cancer Res. 2025 Nov 13. [Abstract]
- Cancer Lett. 2021 Nov 1:520:243-254. [Abstract]
- Cell Commun Signal. 2024 Jan 18;22(1):53. [Abstract]
- Int J Biol Macromol. 2025 Oct 9;330(Pt 3):148223. [Abstract]
- Phytomedicine. 2026 Apr:153:157937. [Abstract]
- Phytomedicine. 2025 Oct 13:148:157385. [Abstract]
- EMBO Mol Med. 2025 Jun 12. [Abstract]
- Phytomedicine. 2024 Jun:128:155425. [Abstract]
- EMBO J. 2023 Jan 16;42(2):e111268. [Abstract]
- Free Radic Biol Med. 2026 Mar 16:246:35-50. [Abstract]
- Free Radic Biol Med. 2025 Nov:239:116-129. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:15-27. [Abstract]
- Brain Behav Immun. 2025 Oct 23:131:106148. [Abstract]
- Alzheimers Res Ther. 2025 Feb 14;17(1):43. [Abstract]
- Biomed Pharmacother. 2022 Nov:155:113669. [Abstract]
- Food Science and Human Wellness. 2023 Nov,12(6),2232-2241.
- Aging Cell. 2023 Aug;22(8):e13896. [Abstract]
- Cell Death Discov. 2025 Oct 6;11(1):445. [Abstract]
- Cell Rep. 2023 Apr 20;42(5):112424. [Abstract]
- Cell Rep. 2023 Mar 30;42(4):112314. [Abstract]
- Neural Regen Res. 2023 Aug;18(8):1818-1826. [Abstract]
- Int J Nanomedicine. 2025 Nov 24:20:14033-14055. [Abstract]
- J Agric Food Res. 2025 Oct 27;24:102486.
- Antioxid Redox Signal. 2025 Dec 26. [Abstract]
- Hepatol Int. 2024 Jun;18(3):1040-1052. [Abstract]
- Mol Ther Nucleic Acids. 2021 Jul 2:26:135-147. [Abstract]
- Chin Med. 2025 Dec 10;20(1):215. [Abstract]
- Biochem Pharmacol. 2025 Sep 20;242(Pt 2):117358. [Abstract]
- J Ethnopharmacol. 2024 Dec 23:119243. [Abstract]
- J Ethnopharmacol. 2024 Nov 29:340:119128. [Abstract]
- Cells. 2024 Dec 6;13(23):2016. [Abstract]
- Life Sci. 2025 May 21:123753. [Abstract]
- Life Sci. 2025 Apr 1:366-367:123476. [Abstract]
- Inflammation. 2025 Apr;48(2):696-712. [Abstract]
- Int J Mol Sci. 2023 Jun 9;24(12):9954. [Abstract]
- Pharmaceuticals (Basel). 2023 Feb 17;16(2):316. [Abstract]
- Eur J Pharmacol. 2025 Feb 6:177359. [Abstract]
- Int Immunopharmacol. 2024 Jun 24:138:112518. [Abstract]
- Int Immunopharmacol. 2022 Sep:110:109000. [Abstract]
- Mol Neurobiol. 2025 May 22. [Abstract]
- Mol Neurobiol. 2024 May;61(5):2949-2963. [Abstract]
- Microorganisms. 2026 Feb 26;14(3):539. [Abstract]
- Mediators Inflamm. 2025 Feb 13:2025:7942947. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jun 9:167288. [Abstract]
- Lab Invest. 2022 Feb;102(2):194-203. [Abstract]
- iScience. 2021 Sep 25;24(10):103170. [Abstract]
- Pestic Biochem Physiol. 2023 Dec:197:105647. [Abstract]
- J Neurochem. 2021 Sep;158(5):1110-1130. [Abstract]
- Sci Rep. 2025 Nov 18;15(1):40630. [Abstract]
- J Virol. 2025 Nov 25:e0147825. [Abstract]
- Int J Obes. 2023 Apr;47(4):325-334. [Abstract]
- Brain Res Bull. 2025 Oct 3:232:111568. [Abstract]
- Dis Model Mech. 2024 Oct 1;17(10):dmm050900. [Abstract]
- J Cancer. 2024 Jun 11;15(13):4406-4416. [Abstract]
- PPAR Res. 2021 Aug 25:2021:6086265. [Abstract]
- Biol Reprod. 2026 Jan 19:ioag014. [Abstract]
- Immunopharmacol Immunotoxicol. 2025 Oct;47(5):716-726. [Abstract]
- Arch Biochem Biophys. 2022 Sep 30:727:109325. [Abstract]
- J Reprod Immunol. 2025 Jul 27:171:104630. [Abstract]
- Front Cardiovasc Med. 2022 Jun 2;9:907747. [Abstract]
- Insects. 2019 Feb 20;10(2):58. [Abstract]
- J Integr Neurosci. 2025 Aug 22;24(8):39286. [Abstract]
- Exp Eye Res. 2025 Oct:259:110509. [Abstract]
- J Integr Neurosci. 2025 Jun 19;24(6):37182. [Abstract]
- PLoS One. 2025 Jun 27;20(6):e0326687. [Abstract]
- Addict Biol. 2024 Mar;29(3):e13382. [Abstract]
- Physiol Behav. 2025 Aug 7:301:115059. [Abstract]
- Dig Dis Sci. 2025 Jun 24. [Abstract]
- Liver Res. 2023 Jun 2;7(2):124-135. [Abstract]
- Epilepsy Res. 2023 Jul:193:107161. [Abstract]
- bioRxiv. 2026 Feb 26.
- Res Sq. 2026 Jan 23.
- Patent. US20250319053A1.
- SSRN. 2025 Sep 19.
- bioRxiv. 2025 Aug 3:2025.08.03.668359. [Abstract]
- bioRxiv. 2025 Jul 11:2025.07.08.661805. [Abstract]
- hLife. 2025 Jan 25.
- bioRxiv. 2024 September 30.
- Res Sq. 2024 Jun 26.
- Research Square Preprint. 2023 Dec 1.
- University of Michigan. 2023 Sep.
- Research Square Preprint. 2023 Sep 8.
- Research Square Preprint. 2023 Aug 7.
- Universidad de Granada. 2023 Mar 27.
- Research Square Print. 2023 Mar 23.
Biological Activity
Tween 80 (Polysorbate 80) is a surfactant which can also reduce bacterial attachment and inhibit biofilm formation[1]. Solubility enhancement as high as 100-fold is achieved using 1% Tween 80 in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9005-65-6
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Appearance Liquid (Density: 1.1 g/cm3)
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Molecular Weight 1309.63
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Formula C64H124O26
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Color Colorless to light yellow
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SMILES
[Tween 80]
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Synonyms
Polysorbate 80
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (111)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Lipocalin-2 drives brain metastatic progression through reciprocal tumor-microenvironment interactions in lung cancer. [Abstract]2025 Dec 24;10(1):417. PMID: 41436606 -
Signal Transduct Target Ther
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors. [Abstract]2023 Sep 25;8(1):366. PMID: 37743418 -
Nature
2026 May;653(8113):254-264. PMID: 42020743 -
Cell
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. [Abstract]2021 Sep 2;184(18):4753-4771.e27. PMID: 34388391 -
Mol Cancer
2024 Apr 27;23(1):85. PMID: 38678233 -
Immunity
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging. [Abstract]2024 Mar 12;57(3):513-527.e6. PMID: 38262419 -
Nat Metab
Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes. [Abstract]2026 Jan;8(1):139-158. PMID: 41482566 -
Cancer Res
Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. [Abstract]2021 Apr 1;81(7):1813-1826. PMID: 33495232 -
Nat Commun
Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies. [Abstract]2025 Oct 7;16(1):8906. PMID: 41057323 -
Nat Commun
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway. [Abstract]2025 Jan 3;16(1):289. PMID: 39753529 -
Nat Commun
2023 May 24;14(1):2994. PMID: 37225695 -
Nat Commun
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. [Abstract]2023 May 19;14(1):2859. PMID: 37208329 -
Acta Pharm Sin B
Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling. [Abstract]2023 Jun;13(6):2680-2700. PMID: 37425037 -
Adv Sci (Weinh)
Malignant Hepatoblast-Like Cells Sustain Stemness via IGF2-Dependent Cholesterol Accumulation in Hepatoblastoma. [Abstract]2025 Apr 24:e2407671. PMID: 40271711 -
Adv Sci (Weinh)
Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape. [Abstract]2024 Jul;11(26):e2306348. PMID: 38696655 -
Nat Chem Biol
2025 Sep 15. PMID: 40954224 -
J Clin Invest
Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models. [Abstract]2024 Jun 17;134(12):e177172. PMID: 38950288 -
Theranostics
2024 Aug 26;14(14):5429-5442. PMID: 39310100 -
Theranostics
2024 May 13;14(8):3029-3042. PMID: 38855187 -
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J Exp Clin Cancer Res
Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy. [Abstract]2025 Jul 2;44(1):181. PMID: 40605065 -
Sci Adv
Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling. [Abstract]2025 Sep 26;11(39):eadq7665. PMID: 40991686 -
Sci Adv
2025 Aug 15;11(33):eadx6587. PMID: 40815641 -
Int J Oral Sci
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma. [Abstract]2024 Jun 18;16(1):46. PMID: 38886342 -
Redox Biol
Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence. [Abstract]2025 Dec:88:103939. PMID: 41308252 -
Biomark Res
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia. [Abstract]2023 Jan 24;11(1):8. PMID: 36691065 -
Clin Cancer Res
Ibrutinib and PD-1 blockade potentiate mesothelin-targeting CAR-T cell therapy in preclinical models of pancreatic cancer. [Abstract]2025 Nov 13. PMID: 41231131 -
Cancer Lett
Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance. [Abstract]2021 Nov 1:520:243-254. PMID: 34339801 -
Cell Commun Signal
Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis. [Abstract]2024 Jan 18;22(1):53. PMID: 38238728 -
Int J Biol Macromol
The role of solute carrier family 16 member 3 protein in hepatocellular carcinoma and sorafenib resistance. [Abstract]2025 Oct 9;330(Pt 3):148223. PMID: 41075888 -
Phytomedicine
Cyasterone regulates lipid metabolism and autophagy mediated by the AMPK signaling pathway to improve KOA synovitis. [Abstract]2026 Apr:153:157937. PMID: 41687535 -
Phytomedicine
Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis. [Abstract]2025 Oct 13:148:157385. PMID: 41086673 -
EMBO Mol Med
Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration. [Abstract]2025 Jun 12. PMID: 40506610 -
Phytomedicine
Wogonin improves colitis by activating the AhR pathway to regulate the plasticity of ILC3/ILC1. [Abstract]2024 Jun:128:155425. PMID: 38518634 -
EMBO J
2023 Jan 16;42(2):e111268. PMID: 36408830 -
Free Radic Biol Med
Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. [Abstract]2026 Mar 16:246:35-50. PMID: 41520847 -
Free Radic Biol Med
Linarin alleviates high-fat diet-induced hepatic steatosis by inhibiting PDE4D and activating the cAMP/PKA/CREB pathway. [Abstract]2025 Nov:239:116-129. PMID: 40712988 -
Free Radic Biol Med
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation. [Abstract]2024 Aug 1:220:15-27. PMID: 38679301 -
Brain Behav Immun
Microglia-mediated Perineuronal nets loss contributes to social memory deficit in male mice after repeated neonatal sevoflurane exposure. [Abstract]2025 Oct 23:131:106148. PMID: 41138885 -
Alzheimers Res Ther
Pathway-based network medicine identifies novel natural products for Alzheimer's disease. [Abstract]2025 Feb 14;17(1):43. PMID: 39953559 -
Biomed Pharmacother
PARP1 inhibition by Olaparib reduces the lethality of pancreatic cancer cells and increases their sensitivity to Gemcitabine. [Abstract]2022 Nov:155:113669. PMID: 36113257 -
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Aging Cell
A rationally designed fluorescence probe achieves highly specific and long-term detection of senescence in vitro and in vivo. [Abstract]2023 Aug;22(8):e13896. PMID: 37312431 -
Cell Death Discov
Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma. [Abstract]2025 Oct 6;11(1):445. PMID: 41053160 -
Cell Rep
CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue. [Abstract]2023 Apr 20;42(5):112424. PMID: 37086405 -
Cell Rep
2023 Mar 30;42(4):112314. PMID: 37000627 -
Neural Regen Res
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease. [Abstract]2023 Aug;18(8):1818-1826. PMID: 36751811 -
Int J Nanomedicine
GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress. [Abstract]2025 Nov 24:20:14033-14055. PMID: 41321900 -
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Antioxid Redox Signal
Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage. [Abstract]2025 Dec 26. PMID: 41468154 -
Hepatol Int
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation. [Abstract]2024 Jun;18(3):1040-1052. PMID: 38172440 -
Mol Ther Nucleic Acids
ac4C acetylation of RUNX2 catalyzed by NAT10 spurs osteogenesis of BMSCs and prevents ovariectomy-induced bone loss. [Abstract]2021 Jul 2:26:135-147. PMID: 34513300 -
Chin Med
Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition. [Abstract]2025 Dec 10;20(1):215. PMID: 41372934 -
Biochem Pharmacol
HIF-1α/A2BAR signalling pathway alleviates kidney fibrosis after ischemia-reperfusion injury by preventing macrophage-to-myofibroblast transition. [Abstract]2025 Sep 20;242(Pt 2):117358. PMID: 40983151 -
J Ethnopharmacol
San Huang Xiao Yan recipe promoted wound healing in diabetic ulcer mice by inhibiting Th17 cell differentiation. [Abstract]2024 Dec 23:119243. PMID: 39722327 -
J Ethnopharmacol
Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice. [Abstract]2024 Nov 29:340:119128. PMID: 39617084 -
Cells
Riluzole Reverses Blood-Testis Barrier Loss to Rescue Chemotherapy-Induced Male Infertility by Binding to TRPC. [Abstract]2024 Dec 6;13(23):2016. PMID: 39682764 -
Life Sci
Transcranial direct current stimulation alleviates chronic pain in knee osteoarthritis by modulating microglial and astrocytic polarization and neuroinflammation. [Abstract]2025 May 21:123753. PMID: 40409582 -
Life Sci
Oxalate stimulates macrophage secretion of prostaglandin E2 to promote renal tubular epithelial cell osteogenesis. [Abstract]2025 Apr 1:366-367:123476. PMID: 39986650 -
Inflammation
Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury. [Abstract]2025 Apr;48(2):696-712. PMID: 38913144 -
Int J Mol Sci
PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice. [Abstract]2023 Jun 9;24(12):9954. PMID: 37373102 -
Pharmaceuticals (Basel)
Therapeutic Effect of Costunolide in Autoimmune Hepatitis: Network Pharmacology and Experimental Validation. [Abstract]2023 Feb 17;16(2):316. PMID: 37163367 -
Eur J Pharmacol
2025 Feb 6:177359. PMID: 39922422 -
Int Immunopharmacol
Targeting lipid peroxidation-associated ferroptosis suppresses lung carcinoma progression by regulating cell cycle arrest. [Abstract]2024 Jun 24:138:112518. PMID: 38917528 -
Int Immunopharmacol
JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis. [Abstract]2022 Sep:110:109000. PMID: 35777266 -
Mol Neurobiol
Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways. [Abstract]2025 May 22. PMID: 40402410 -
Mol Neurobiol
Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain. [Abstract]2024 May;61(5):2949-2963. PMID: 37957422 -
Microorganisms
The Effect of Variations in Temperature and Contact Time of Zingerone, [6]-Gingerol and Shogaol as Disinfectants on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. [Abstract]2026 Feb 26;14(3):539. PMID: 41900299 -
Mediators Inflamm
Selenium Nanoparticles Decorated With Stevioside Potentially Attenuate Fructose Palmitate Induced Lipid Accumulation in HepG2 Cells. [Abstract]2025 Feb 13:2025:7942947. PMID: 39981401 -
Biochim Biophys Acta Mol Basis Dis
Effect of alternating nicotinamide phosphoribosyltransferase expression levels on mitophagy in Alzheimer's disease mouse models. [Abstract]2024 Jun 9:167288. PMID: 38862096 -
Lab Invest
Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA damage in glioblastoma. [Abstract]2022 Feb;102(2):194-203. PMID: 34625658 -
iScience
2021 Sep 25;24(10):103170. PMID: 34646996 -
Pestic Biochem Physiol
2-Methoxyestradiol ameliorates paraquat-induced pulmonary fibrosis by inhibiting the TGF-β1/Smad2/3 signaling pathway. [Abstract]2023 Dec:197:105647. PMID: 38072522 -
J Neurochem
Spinal Nrf2 translocation may inhibit neuronal NF-κB activation and alleviate allodynia in a rat model of bone cancer pain. [Abstract]2021 Sep;158(5):1110-1130. PMID: 34254317 -
Sci Rep
PTPRK promotes resiniferatoxin-induced postherpetic neuralgia via activating DUSP1/p38 MAPK signaling pathway in dorsal root ganglia. [Abstract]2025 Nov 18;15(1):40630. PMID: 41253902 -
J Virol
Broad-spectrum inhibition of influenza A virus replication by blocking the nuclear export of viral ribonucleoprotein complexes. [Abstract]2025 Nov 25:e0147825. PMID: 41288076 -
Int J Obes
2023 Apr;47(4):325-334. PMID: 36782056 -
Brain Res Bull
ATF3 enhancement of CHAC1 expression: A pathway to neuronal ferroptosis in spinal cord injury. [Abstract]2025 Oct 3:232:111568. PMID: 41046987 -
Dis Model Mech
Sex hormone receptors, calcium-binding protein and Yap1 signaling regulate sex-dependent liver cell proliferation following partial hepatectomy. [Abstract]2024 Oct 1;17(10):dmm050900. PMID: 39397390 -
J Cancer
Treatment of HNSC and pulmonary metastasis using the anti-helminthic drug niclosamide to modulate Stat3 signaling activity. [Abstract]2024 Jun 11;15(13):4406-4416. PMID: 38947381 -
PPAR Res
Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR- γ to Inhibit the NF- κ B/NLRP3 Inflammatory Axis in Spinal Cord Neurons. [Abstract]2021 Aug 25:2021:6086265. PMID: 34484316 -
Biol Reprod
2026 Jan 19:ioag014. PMID: 41553274 -
Immunopharmacol Immunotoxicol
All- trans retinoic acid ameliorates S100-induced experimental autoimmune hepatitis by regulating the Treg/Th17 balance. [Abstract]2025 Oct;47(5):716-726. PMID: 40936263 -
Arch Biochem Biophys
Oxalate induces the ossification of RTECs by activating the JAK2/STAT3 signaling pathway and participates in the formation of kidney stones. [Abstract]2022 Sep 30:727:109325. PMID: 35749806 -
J Reprod Immunol
Association of elevated ACSL4 expression with impaired endometrial receptivity in endometriosis and restoration by ACSL4 inhibitor PRGL493. [Abstract]2025 Jul 27:171:104630. PMID: 40763450 -
Front Cardiovasc Med
GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis. [Abstract]2022 Jun 2;9:907747. PMID: 35722096 -
Insects
Laboratory and Greenhouse Evaluation of a Granular Formulation of Beauveria bassiana for Control of Western Flower Thrips, Frankliniella occidentalis. [Abstract]2019 Feb 20;10(2):58. PMID: 30791617 -
J Integr Neurosci
Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice. [Abstract]2025 Aug 22;24(8):39286. PMID: 40919625 -
Exp Eye Res
2025 Oct:259:110509. PMID: 40633646 -
J Integr Neurosci
Idebenone Orchestrates Anti-Inflammatory and Antioxidant Responses to Alleviate Brain Injury After Intracerebral Hemorrhage in Mice. [Abstract]2025 Jun 19;24(6):37182. PMID: 40613371 -
PLoS One
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy. [Abstract]2025 Jun 27;20(6):e0326687. PMID: 40577270 -
Addict Biol
Involvement of nucleus accumbens SERCA2b in methamphetamine-induced conditioned place preference. [Abstract]2024 Mar;29(3):e13382. PMID: 38488467 -
Physiol Behav
Acupuncture waggle needling alleviates spastic movement disorder in post-stroke rats via GLT-1 activation to modulate Glu/GABA-Gln cycle. [Abstract]2025 Aug 7:301:115059. PMID: 40783057 -
Dig Dis Sci
Targeting TREM1 Ameliorates Necrotizing Enterocolitis in Neonatal Mice by Inhibiting Endoplasmic Reticulum Stress and Regulating Macrophage Polarization. [Abstract]2025 Jun 24. PMID: 40553398 -
Liver Res
Glucokinase activator improves glucose tolerance and induces hepatic lipid accumulation in mice with diet-induced obesity. [Abstract]2023 Jun 2;7(2):124-135. PMID: 39958949 -
Epilepsy Res
Inhibition of mTORC2 improves brain injury in epileptic rats by promoting chaperone-mediated autophagy. [Abstract]2023 Jul:193:107161. PMID: 37163909 -
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bioRxiv
On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions. [Abstract]2025 Aug 3:2025.08.03.668359. PMID: 40766692 -
bioRxiv
Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy Strategy. [Abstract]2025 Jul 11:2025.07.08.661805. PMID: 40672274 -
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Solvent & Solubility
DMSO : ≥ 100 mg/mL (76.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (38.18 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.91 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (1.91 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Brandl MT, et al. Effect of the surfactant tween 80 on the detachment and dispersal of Salmonella enterica serovar Thompson single cells and aggregates from cilantro leaves as revealed by image analysis. Appl Environ Microbiol. 2014 Aug;80(16):5037-42. [Content Brief]
[2]. Pan Y, et al. Pharmacokinetics study of ferulic acid in rats after oral administration of γ-oryzanol under combined use of Tween 80 by LC/MS/MS. Eur Rev Med Pharmacol Sci. 2014;18(2):143-50. [Content Brief]
[3]. C A Castro, et al.Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmacol Biochem Behav. 1995 Apr;50(4):521-6. [Content Brief]
[4]. Varma RK, Kaushal R, Junnarkar AY, et al. Polysorbate 80: a pharmacological study. Arzneimittelforschung. 1985;35(5):804-808. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.7636 mL | 3.8179 mL | 7.6357 mL | 19.0894 mL |
| 5 mM | 0.1527 mL | 0.7636 mL | 1.5271 mL | 3.8179 mL | |
| 10 mM | 0.0764 mL | 0.3818 mL | 0.7636 mL | 1.9089 mL | |
| 15 mM | 0.0509 mL | 0.2545 mL | 0.5090 mL | 1.2726 mL | |
| 20 mM | 0.0382 mL | 0.1909 mL | 0.3818 mL | 0.9545 mL | |
| 25 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.7636 mL | |
| 30 mM | 0.0255 mL | 0.1273 mL | 0.2545 mL | 0.6363 mL | |
| DMSO | 40 mM | 0.0191 mL | 0.0954 mL | 0.1909 mL | 0.4772 mL |
| 50 mM | 0.0153 mL | 0.0764 mL | 0.1527 mL | 0.3818 mL | |
| 60 mM | 0.0127 mL | 0.0636 mL | 0.1273 mL | 0.3182 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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