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Cat. No.: HY-158049

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Anticancer agent 199

Anticancer agent 199 (Compound G-4) induces apoptosis in triple negative breast cancer (TNBC) cells via the mitochondrial pathway through inhibiting EGFR, AKT and MAPK pathways. Anticancer agent 199 also induces Ferroptosis by down-regulating LCN2. Anticancer agent 199 inhibits TNBC cell viability and migration, and induces S phase cell cycle arrest. Anticancer agent 199 is a derivate of cyclin-dependent kinase inhibitor Rocovitine.

For research use only. We do not sell to patients.

CAS No.: 2422001-24-7
Formula: C₂₉H₃₉ClFN₇O
Molecular Weight:556.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Anticancer agent 199 Chemical Structure

CAS No.: 2422001-24-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.54 μM Compound: 3i	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HCT-116	IC₅₀	2.95 μM Compound: 3i	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HepG2	IC₅₀	1.75 μM Compound: 3i	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
HT-29	IC₅₀	4.21 μM Compound: 3i	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
K562	IC₅₀	2.63 μM Compound: 3i	Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
MCF7	IC₅₀	2.83 μM Compound: 3i	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
MGC-803	IC₅₀	19.89 μM Compound: 3i	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
NCI-H1299	IC₅₀	4.77 μM Compound: 3i	Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]
PC-3	IC₅₀	7.2 μM Compound: 3i	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 37708799]

Chemical Information

CAS No. 2422001-24-7
Molecular Weight 556.12
Formula C₂₉H₃₉ClFN₇O
SMILES

OCCN1CCC(CC1)C2CCN(CC2)C3=NC4=C(C(NCC5=CC=C(C(F)=C5)Cl)=N3)N=CN4C6CCCC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun G, et al. G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis. Bioc [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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