BNIP3 - BCL2 interacting protein 3 Gene

Also Known as NIP3; HABON

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 664

About BNIP3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:131,967,684-131,981,923 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 54.5), fat (RPKM 52.6) and 24 other tissues.

Summary

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]

BNIP3 Products (1)

mRNA	Protein	Name
NM_004052.4	NP_004043.4	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	20436456	GOA
enables endoplasmic reticulum-autophagosome adaptor activity	IDA IDA: Inferred from direct assay	22505714	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10381623	GOA
enables mitochondrion autophagosome adaptor activity	IDA IDA: Inferred from direct assay	22505714	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7954800	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9396766	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to cobalt ion	IMP IMP: Inferred from mutant phenotype	20436456	GOA
acts upstream of or within cellular response to hypoxia	IGI IGI: Inferred from genetic interaction	19273585	GOA
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	20436456	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	9973195	GOA
involved in granzyme-mediated programmed cell death signaling pathway	IDA IDA: Inferred from direct assay	9396766	GOA
involved in intrinsic apoptotic signaling pathway in response to hypoxia	IMP IMP: Inferred from mutant phenotype	20436456	GOA
involved in mitochondrial fragmentation involved in apoptotic process	IDA IDA: Inferred from direct assay	20436456	GOA
involved in mitochondrial outer membrane permeabilization	IDA IDA: Inferred from direct assay	18371312	GOA
involved in mitochondrial protein catabolic process	IMP IMP: Inferred from mutant phenotype	22292033	GOA
involved in mitophagy	IMP IMP: Inferred from mutant phenotype	22505714	GOA
involved in negative regulation of membrane potential	IDA IDA: Inferred from direct assay	10891486	GOA
involved in negative regulation of mitochondrial fusion	IDA IDA: Inferred from direct assay	20436456	GOA
acts upstream of or within negative regulation of programmed cell death	IGI IGI: Inferred from genetic interaction	19273585	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9973195	GOA
acts upstream of or within positive regulation of macroautophagy	IGI IGI: Inferred from genetic interaction	19273585	GOA
involved in positive regulation of mitochondrial fission	IDA IDA: Inferred from direct assay	20436456	GOA
involved in positive regulation of programmed cell death	IDA IDA: Inferred from direct assay	10891486	GOA
involved in positive regulation of protein-containing complex disassembly	IDA IDA: Inferred from direct assay	20436456	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	20436456	GOA
involved in reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	10891486	GOA
involved in regulation of mitochondrial membrane permeability	IDA IDA: Inferred from direct assay	10891486	GOA
involved in reticulophagy	IMP IMP: Inferred from mutant phenotype	22505714	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	22505714	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	10891486	GOA
located in mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	9396766	GOA
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22505714	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	10891486	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	7954800	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	7954800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIP3 Protein Structure

BNIP3

0
100
194 a.a.

Protein Preferred Names	Protein Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	BCL2/adenovirus E1B 19kDa interacting protein 3

BNIP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BNIP3	Q12983	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	32296183
Intra	BNIP3	Q12983	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	25416956
Intra	BNIP3	Q12983	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	BNIP3	Q12983	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	25416956
Intra	BNIP3	Q12983	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	BNIP3	Q12983	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	BNIP3	Q12983	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	BNIP3	Q12983	OPA1	Homo sapiens	O60313	Y2H	20436456
Intra	BNIP3	Q12983	OPA1	Homo sapiens	O60313	Pull Down	20436456
Intra	BNIP3	Q12983	OPA1	Homo sapiens	O60313	Anti Tag CoIP	20436456
Intra	BNIP3	Q12983	OPA1	Homo sapiens	O60313	Anti Bait CoIP	20436456
Intra	BNIP3	Q12983	REEP2	Homo sapiens	Q9BRK0	Validated Y2H	32296183
Intra	BNIP3	Q12983	REEP2	Homo sapiens	Q9BRK0	Y2H Array	32296183
Intra	BNIP3	Q12983	REEP2	Homo sapiens	Q9BRK0	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	BNIP3	Q12983	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	BNIP3	Q12983	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	BNIP3	Q12983	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Array	32296183
Intra	BNIP3	Q12983	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	BNIP3	Q12983	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	BNIP3	Q12983	KTN1	Homo sapiens	Q86UP2-3	Validated Y2H	32296183
Intra	BNIP3	Q12983	CD3E	Homo sapiens	P07766	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	CD3E	Homo sapiens	P07766	Y2H Array	32296183
Intra	BNIP3	Q12983	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	BNIP3	Q12983	SLC35B1	Homo sapiens	P78383	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	SLC35B1	Homo sapiens	P78383	Y2H Array	32296183
Intra	BNIP3	Q12983	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	BNIP3	Q12983	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	BNIP3	Q12983	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	BNIP3	Q12983	HPN	Homo sapiens	P05981	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	HPN	Homo sapiens	P05981	Y2H Array	32296183
Intra	BNIP3	Q12983	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	BNIP3	Q12983	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	BNIP3	Q12983	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	BNIP3	Q12983	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	BNIP3	Q12983	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	RNF24	Homo sapiens	Q9Y225-2	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	RNF24	Homo sapiens	Q9Y225-2	Validated Y2H	32296183
Intra	BNIP3	Q12983	RNF24	Homo sapiens	Q9Y225-2	Y2H Array	32296183
Intra	BNIP3	Q12983	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	BNIP3	Q12983	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	BNIP3	Q12983	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	BNIP3	Q12983	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	BNIP3	Q12983	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	BNIP3	Q12983	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	BNIP3	Q12983	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	BNIP3	Q12983	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	BNIP3	Q12983	SLC31A2	Homo sapiens	O15432	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	SLC31A2	Homo sapiens	O15432	Y2H Array	32296183
Intra	BNIP3	Q12983	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	BNIP3	Q12983	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	BNIP3	Q12983	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	BNIP3	Q12983	CLDN9	Homo sapiens	O95484	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	CLDN9	Homo sapiens	O95484	Y2H Array	32296183
Intra	BNIP3	Q12983	SLC6A17	Homo sapiens	Q9H1V8	Validated Y2H	32296183
Intra	BNIP3	Q12983	SLC6A17	Homo sapiens	Q9H1V8	Y2H Array	32296183
Intra	BNIP3	Q12983	SLC6A17	Homo sapiens	Q9H1V8	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	RNASEK	Homo sapiens	Q6P5S7	Validated Y2H	32296183
Intra	BNIP3	Q12983	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	BNIP3	Q12983	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	BNIP3	Q12983	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	BNIP3	Q12983	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	BNIP3	Q12983	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	BNIP3	Q12983	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	BNIP3	Q12983	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	BNIP3	Q12983	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	BNIP3	Q12983	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	BNIP3	Q12983	KTN1	Homo sapiens	Q86UP2	Y2H Prey Pooling	25416956
Intra	BNIP3	Q12983	KTN1	Homo sapiens	Q86UP2	Validated Y2H	25416956
Intra	BNIP3	Q12983	KTN1	Homo sapiens	Q86UP2	Y2H Array	25416956
Intra	BNIP3	Q12983	MFSD14B	Homo sapiens	Q5SR56	Validated Y2H	32296183
Intra	BNIP3	Q12983	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	BNIP3	Q12983	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	BNIP3	Q12983	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	BNIP3	Q12983	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	BNIP3	Q12983	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
Intra	BNIP3	Q12983	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
Intra	BNIP3	Q12983	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
Intra	BNIP3	Q12983	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	BNIP3	Q12983	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	BNIP3	Q12983	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	BNIP3	Q12983	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	BNIP3	Q12983	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	BNIP3	Q12983	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	BNIP3	Q12983	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	BNIP3	Q12983	TMEM11	Homo sapiens	P17152	Validated Y2H	27107012
Intra	BNIP3	Q12983	TMEM11	Homo sapiens	P17152	Y2H Pooling	16189514
Intra	BNIP3	Q12983	TMEM11	Homo sapiens	P17152	Anti Tag CoIP	33961781
Intra	BNIP3	Q12983	TMEM11	Homo sapiens	P17152	Anti Tag CoIP	28514442
Intra	BNIP3	Q12983	TMEM11	Homo sapiens	P17152	Y2H Prey Pooling	25416956
Intra	BNIP3	Q12983	TMEM11	Homo sapiens	P17152	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	TMEM11	Homo sapiens	P17152	Y2H Array	32296183
Intra	BNIP3	Q12983	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	BNIP3	Q12983	SMIM3	Homo sapiens	Q9BZL3	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	32296183
Intra	BNIP3	Q12983	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	BNIP3	Q12983	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	BNIP3	Q12983	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
Intra	BNIP3	Q12983	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	BNIP3	Q12983	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Validated Y2H	25416956
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Anti Tag CoIP	33961781
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Anti Tag CoIP	28514442
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Y2H Array	25416956
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Y2H	10381623
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	SLC	27107012
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	BFG-2H	27107012
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Y2H	21516116
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Y2H Pooling	16189514
Intra	BNIP3	Q12983	BNIP3L	Homo sapiens	O60238	Validated Y2H	27107012
Intra	BNIP3	Q12983	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	BNIP3	Q12983	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	BNIP3	Q12983	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	BNIP3	Q12983	SEC23A	Homo sapiens	Q15436	Validated Y2H	32296183
Intra	BNIP3	Q12983	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	BNIP3	Q12983	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183
Intra	BNIP3	Q12983	EBAG9	Homo sapiens	O00559	Y2H Array	32296183
Intra	BNIP3	Q12983	PPTC7	Homo sapiens	Q8NI37	Y2H Array	32296183
Intra	BNIP3	Q12983	PPTC7	Homo sapiens	Q8NI37	Validated Y2H	32296183
Intra	BNIP3	Q12983	PPTC7	Homo sapiens	Q8NI37	Anti Tag CoIP	33961781
Intra	BNIP3	Q12983	PPTC7	Homo sapiens	Q8NI37	Anti Tag CoIP	28514442
Intra	BNIP3	Q12983	PPTC7	Homo sapiens	Q8NI37	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BNIP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7670	BNIP3/NIP3 Protein, Human (His)	AAH21989.1 (M1-L166)	≥ 95%, as determined by reducing SDS-PAGE.

BNIP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80035	BNIP3 Antibody (YA580)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P84524	BNIP3 Antibody (YA4221)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84524A	BNIP3 Antibody (YA4221)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hereditary Leiomyomatosis And Renal Cell Cancer	HLRCC Lrcc Mcl Multiple Cutaneous And Uterine Leiomyomata Leiomyomatosis And Renal Cell Cancer Mcul Mcul1 Familial Leiomyomatosis And Renal Cell Cancer Familial Leiomyomatosis Cutis Et Uteri Familial Leiomyomatosis With Renal Carcinoma Familial Multiple Cutaneous Leiomyomas Reed'S Syndrome Multiple Cutaneous And Uterine Leiomyomata 1, With Or Without Renal Cell Carcinoma Leiomyomatosis And Renal Cell Cancer, Hereditary Leiomyoma, Multiple Cutaneous Multiple Cutaneous Leiomyomata Hereditary Leiomyomatosis And Renal Cell Carcinoma Multiple Cutaneous Leiomyoma Hereditary Leiomyomatosis Hereditary Leiomyomatosis With Renal Carcinoma Hereditary Multiple Cutaneous Leiomyomas Multiple Cutaneous And Uterine Leiomyomas Reed Syndrome Leiomyoma Multiple Cutaneous Leiomyomatosis And Renal Cell Cancer Hereditary Multiple Cutaneous And Uterine Leiomyomata 1 With Or Without Renal Cell Carcinoma
Leiomyomatosis
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Adrenal Gland Pheochromocytoma	Pheochromocytoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Bone Cancer	Malignant Bone Neoplasm Bone Carcinoma Bone Neoplasms Bone Neoplasm Bone Tumour Ca - Bone Cancer Malignant Bone Tumour Malignant Neoplasm Of Bone Malignant Osseous Tumor Neoplasm Of Bone Osseous Tumor Osteosarcoma Of Bone Osteogenic Neoplasm
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121859	RU28362	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BNIP3	VGNC	VGNC:70273
Rattus norvegicus	BNIP3	RGD	RGD:620800
Canis familiaris	BNIP3	VGNC	VGNC:38493
Mus musculus	BNIP3	MGD	MGI:109326
Bos taurus	BNIP3	VGNC	VGNC:26533
Others	BNIP3	NCBI