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Cat. No.: HY-N19832

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Icariside E3

Icariside E3 is a Leishmania donovani DNA Topoisomerase IB (LdTOP1LS) inhibitor. Icariside E3 can be used for the research of leishmaniasis.

For research use only. We do not sell to patients.

CAS No.: 117613-74-8
Formula: C₂₆H₃₆O₁₁
Molecular Weight:524.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Icariside E3 Chemical Structure

CAS No.: 117613-74-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Icariside E3 is a Leishmania donovani DNA Topoisomerase IB (LdTOP1LS) inhibitor. Icariside E3 can be used for the research of leishmaniasis^[1].

All Topoisomerase Isoforms :

All Parasite Isoforms :

In Vitro

Icariside E3 (10-100 μM; 30 min) potently inhibits Leishmania donovani DNA topoisomerase IB (LdTOP1LS)-mediated plasmid relaxation in a dose-dependent manner, achieving 94% inhibition at 50 μM and total inhibition at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 117613-74-8
Molecular Weight 524.56
Formula C₂₆H₃₆O₁₁
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=C(OC)C=C(CCCO)C=C2C(CC3=CC=C(C(OC)=C3)O)CO
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mukherjee T, et al. Saracoside: a new lignan glycoside from Saraca indica, a potential inhibitor of DNA topoisomerase IB. Nat Prod Commun. 2012;7(6):767-769. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Icariside E3

All Topoisomerase Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Icariside E3 Related Classifications

HY-N19832 Related Classifications