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Meglitinide

Meglitinide is an ATP-sensitive potassium (K_ATP) channel inhibitor. Meglitinide exhibits IC₅₀ values of 0.26 μM, 0.53 μM and 1.6 μM against K_ATP channels containing SUR1, SUR2A and SUR2B, respectively, with a K_d value of 7 μM for both SUR1 and SUR2A, and a K_d value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close K_ATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes.

For research use only. We do not sell to patients.

CAS No.: 54870-28-9
Formula: C₁₇H₁₆ClNO₄
Molecular Weight:333.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Meglitinide Chemical Structure

CAS No.: 54870-28-9

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Sample (0.1mg)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	Inhibition	-6.41 % Compound: MEGLITINIDE	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

In Vitro

Meglitinide blocks recombinant Kir6.2/SUR1, Kir6.2/SUR2A, and Kir6.2/SUR2B K_ATP channels with similar affinities, with IC₅₀ values ranging from 0.26 to 1.6 μmol/l across the channel subtypes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 54870-28-9
Molecular Weight 333.77
Formula C₁₇H₁₆ClNO₄
SMILES

O=C(C1=CC=C(CCNC(C2=CC(Cl)=CC=C2OC)=O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Proks P, et al. Sulfonylurea stimulation of insulin secretion. Diabetes. 2002;51 Suppl 3:S368-S376. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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