ppTG21
ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing.
For research use only. We do not sell to patients.
- CAS No.: 380480-77-3
- Formula: C115H173N31O22
- Molecular Weight:2341.80
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
ppTG21 (7.5 nmol ppTG21 salt; 44-48 h) facilitates endosomal escape of Cas9-2lig-1NLS RNP, leading to cell-type specific gene editing with 4.8% indels in HEPG2 cells (ASGPr+); negligible editing occurs in SKHEP cells (ASGPr diminished) with either RNP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 380480-77-3
-
Molecular Weight 2341.80
-
Formula C115H173N31O22
-
Sequence
Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala
-
Sequence Shortening
GLFHALLHLLHSLWHLLLHA
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz