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Cat. No.: HY-100216R

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SPDP (Standard)

(Synonyms: SPDP Crosslinker (Standard); Py-ds-Prp-OSu (Standard))

SPDP (Standard) is the analytical standard of SPDP (HY-100216). This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

CAS No.: 68181-17-9
Formula: C₁₂H₁₂N₂O₄S₂
Molecular Weight:312.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SPDP (Standard) Chemical Structure

CAS No.: 68181-17-9

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 68181-17-9
Molecular Weight 312.37
Formula C₁₂H₁₂N₂O₄S₂
SMILES

O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Synonyms

SPDP Crosslinker (Standard); Py-ds-Prp-OSu (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [Content Brief]

[2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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