2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. (Nle4)-α-MSH

(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

For research use only. We do not sell to patients.

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(Nle4)-α-MSH Chemical Structure

(Nle4)-α-MSH Chemical Structure

CAS No. : 64887-70-3

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(Nle4)-α-MSH Related Antibodies

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Description

(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1].

IC50 & Target

tyrosinase; melanoma adenylate cyclase[1]
In Vitro

(Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity[1].
(Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)[1].
(Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins[1].
(Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Nle4)-α-MSH Related Antibodies
Molecular Weight

1646.85

Formula

C78H111N21O19
CAS No.
Sequence Shortening

Ac-SYS-{Nle}-EHFRWGKPV-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(Nle4)-α-MSH Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Nle4)-α-MSH64887-70-3Melanocortin ReceptorMC Receptorfrog skinheat-alkalimelanocyte-stimulating hormonetyrosinase activityadenylate cyclaseInhibitorinhibitorinhibit

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