2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Norbormide

Norbormide shows vasoconstrictor activity by blocking calcium channel. The activity of Norbormide is species- and tissue-specific, endothelium independent, and is restricted to the peripheral arteries of rat. Norbormide is also a toxicant, and the oral LD50s in mouse, hamster, guinea pig and rabbit are 2250, 140, 620, and 1000 mg/kg.

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Norbormide Chemical Structure

Norbormide Chemical Structure

CAS No. : 991-42-4

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Based on 1 publication(s) in Google Scholar

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Description

Norbormide shows vasoconstrictor activity by blocking calcium channel. The activity of Norbormide is species- and tissue-specific, endothelium independent, and is restricted to the peripheral arteries of rat. Norbormide is also a toxicant, and the oral LD50s in mouse, hamster, guinea pig and rabbit are 2250, 140, 620, and 1000 mg/kg[1].

Molecular Weight

511.57

Formula

C33H25N3O3
CAS No.
SMILES

OC(C1=CC=CC=C1)(C2=CC=CC=N2)C3=CC4/C(C3[C@H](C(N5)=O)[C@@H]4C5=O)=C(C6=CC=CC=N6)/C7=CC=CC=C7
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Room temperature in continental US; may vary elsewhere.
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References
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Norbormide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norbormide991-42-4Calcium ChannelCa2+ channelsCa channelsvasoconstrictorspecies specifictissue specificperipheral arteriesInhibitorinhibitorinhibit

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