2. Metabolic Enzyme/Protease
  3. Thrombin
  4. NP-313

NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow.

For research use only. We do not sell to patients.

NP-313 Chemical Structure

NP-313 Chemical Structure

CAS No. : 5397-78-4

Size Price Stock Quantity
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 770 In-stock
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Based on 1 publication(s) in Google Scholar

NP-313 Related Antibodies

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Description

NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1].

In Vitro

NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner. The maximum inhibition of platelet aggregation induced by thrombin and A23187 was approximately 80% and 60%, respectively[1].
NP-313 (0-8 μM) concentration-dependently inhibited P-selectin expression and thromboxane B 2 (TXB2) production in human platelets induced by collagen or thrombin. Also, NP-313 inhibited COX-1 and TXA 2 synthase with the IC 50 values of 1.5 and 3.9 µM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NP-313 Related Antibodies
In Vivo

NP-313 (i.v., 4-16 µg/g) significantly prolongs occlusion time (TTO), prolongs bleeding time and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

249.65

Formula

C12H8ClNO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(NC(C1=O)=C(Cl)C(C2=C1C=CC=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (100.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0056 mL 20.0280 mL 40.0561 mL
5 mM 0.8011 mL 4.0056 mL 8.0112 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0056 mL 20.0280 mL 40.0561 mL 100.1402 mL
5 mM 0.8011 mL 4.0056 mL 8.0112 mL 20.0280 mL
10 mM 0.4006 mL 2.0028 mL 4.0056 mL 10.0140 mL
15 mM 0.2670 mL 1.3352 mL 2.6704 mL 6.6760 mL
20 mM 0.2003 mL 1.0014 mL 2.0028 mL 5.0070 mL
25 mM 0.1602 mL 0.8011 mL 1.6022 mL 4.0056 mL
30 mM 0.1335 mL 0.6676 mL 1.3352 mL 3.3380 mL
40 mM 0.1001 mL 0.5007 mL 1.0014 mL 2.5035 mL
50 mM 0.0801 mL 0.4006 mL 0.8011 mL 2.0028 mL
60 mM 0.0668 mL 0.3338 mL 0.6676 mL 1.6690 mL
80 mM 0.0501 mL 0.2504 mL 0.5007 mL 1.2518 mL
100 mM 0.0401 mL 0.2003 mL 0.4006 mL 1.0014 mL
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NP-313 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NP-3135397-78-4NP313NP 313Thrombinantithromboticplatelet aggregationthromboxane A 2 Ca2+SOCCInhibitorinhibitorinhibit

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