1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. NSC 80467

NSC 80467 

Cat. No.: HY-137843
Handling Instructions

NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage.

For research use only. We do not sell to patients.

NSC 80467 Chemical Structure

NSC 80467 Chemical Structure

CAS No. : 101982-51-8

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Description

NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage[1].

In Vitro

NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression[1].
NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: PC3 cells
Concentration: 200 or 800 nM
Incubation Time: 24 hours
Result: Associated with inhibition of survivin expression.
Molecular Weight

512.35

Formula

C₂₄H₂₂BrN₃O₅

CAS No.

101982-51-8

SMILES

O=C(C1=C2[N+](CC(C3=CC=C([N+]([O-])=O)C=C3)=O)=C(C)N1CC(C)C)C4=C(C=CC=C4)C2=O.[Br-]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NSC 80467NSC80467NSC-80467DNA/RNA SynthesisDNA damaging synthesis,γH2AXpKAP1NCI-60cellPC3Inhibitorinhibitorinhibit

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NSC 80467
Cat. No.:
HY-137843
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