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Cat. No.: HY-144441

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NSC81111

NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC₅₀ of 0.15 nM. NSC81111 has anticaner effects.

For research use only. We do not sell to patients.

CAS No.: 1678-14-4
Formula: C₁₉H₁₆O₄
Molecular Weight:308.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC81111 Chemical Structure

CAS No.: 1678-14-4

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC₅₀ of 0.15 nM. NSC81111 has anticaner effects^[1].

IC₅₀ & Target

IC50: 0.15 nM (EGFR-TK)^[1]

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	3.81 μM Compound: NSC81111	Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay	[PMID: 34995690]
HeLa	IC₅₀	8.12 μM Compound: NSC81111	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay	[PMID: 34995690]

Chemical Information

CAS No. 1678-14-4
Molecular Weight 308.33
Formula C₁₉H₁₆O₄
SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC(C3=CC=C(OC)C=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nattanan Jiwacharoenchai, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg M [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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