NUN82647
Based on 1 Customer Validation
NUN82647 is a potent cytotoxic compound that inhibits cell cycle at G2 phase and induces apoptosis. NUN82647 can be used for the study of leukemia.
For research use only. We do not sell to patients.
- CAS No.: 16082-64-7
- Formula: C15H13N3O2S
- Molecular Weight:299.36
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
13.5 μM
Compound: 19
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Inhibition of TNFalpha stimulated human NF-kappaB-mediated beta lactamase gene expression in HUVEC
Inhibition of TNFalpha stimulated human NF-kappaB-mediated beta lactamase gene expression in HUVEC
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[PMID: 18024113] |
| HUVEC | IC50 |
2 μM
Compound: 19
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Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC
Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC
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[PMID: 18024113] |
| OCI-Ly3 | IC50 |
>57 μM
Compound: 19
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Cytotoxicity against NF-kappaB overexpressing human OCI-Ly3 cells after 4 hrs
Cytotoxicity against NF-kappaB overexpressing human OCI-Ly3 cells after 4 hrs
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[PMID: 18024113] |
NUN82647 (QBS; 0.001-10 μM; 48 h) induces cell death in Jurkat T cells with an EC50 of 0.77 μM[1].
NUN82647 (1 μM; 48 h) triggers caspase-dependent apoptosis in Jurkat T cells[1].
NUN82647 (0.25-2 μM; 48 h) induces G2 arrest in Jurkat T cells[1].
NUN82647 (1 μM; 6-24 h) increases the levels of cyclin B1 as well as phosphorylated-cdc2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat T cells
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Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
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Incubation Time:48 h
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Result:Induced cell death in Jurkat T cells.
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Cell Line:Jurkat T cells
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Concentration:1 μM
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Incubation Time:48 h
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Result:Induced nuclear condensation, DNA fragmentation and increased the sub-G1 peak.
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Cell Line:Jurkat T cells
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Concentration:0.25 μM, 0.5 μM, 1 μM, 2 μM
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Incubation Time:48 h
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Result:Induced G2 arrest.
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Cell Line:Jurkat T cells
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Concentration:1 μM
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Incubation Time:6 h, 12 h, 18 h, 24 h
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Result:Increased the levels of cyclin B1 as well as phosphorylated-cdc2.
Chemical Information
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CAS No. 16082-64-7
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Appearance Solid
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Molecular Weight 299.36
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Formula C15H13N3O2S
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Color White to off-white
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SMILES
O=S(C1=CC=CC=C1N)(NC2=C3N=CC=CC3=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (417.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3405 mL | 16.7023 mL | 33.4046 mL | 83.5115 mL |
| 5 mM | 0.6681 mL | 3.3405 mL | 6.6809 mL | 16.7023 mL | |
| 10 mM | 0.3340 mL | 1.6702 mL | 3.3405 mL | 8.3511 mL | |
| 15 mM | 0.2227 mL | 1.1135 mL | 2.2270 mL | 5.5674 mL | |
| 20 mM | 0.1670 mL | 0.8351 mL | 1.6702 mL | 4.1756 mL | |
| 25 mM | 0.1336 mL | 0.6681 mL | 1.3362 mL | 3.3405 mL | |
| 30 mM | 0.1113 mL | 0.5567 mL | 1.1135 mL | 2.7837 mL | |
| 40 mM | 0.0835 mL | 0.4176 mL | 0.8351 mL | 2.0878 mL | |
| 50 mM | 0.0668 mL | 0.3340 mL | 0.6681 mL | 1.6702 mL | |
| 60 mM | 0.0557 mL | 0.2784 mL | 0.5567 mL | 1.3919 mL | |
| 80 mM | 0.0418 mL | 0.2088 mL | 0.4176 mL | 1.0439 mL | |
| 100 mM | 0.0334 mL | 0.1670 mL | 0.3340 mL | 0.8351 mL |
NUN82647 Related Classifications
HY-115683 Related Classifications
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