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Cat. No.: HY-189374

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OAT-IN-2

OAT-IN-2 is an ornithine aminotransferase (hOAT) inhibitor. OAT-IN-2 is used in the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

CAS No.: 3057206-96-6
Formula: C₇H₉F₂NO₂
Molecular Weight:177.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

OAT-IN-2 Chemical Structure

CAS No.: 3057206-96-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

OAT-IN-2 is an ornithine aminotransferase (hOAT) inhibitor. OAT-IN-2 is used in the research of hepatocellular carcinoma^[1].

In Vitro

OAT-IN-2 (Compound 5) is a time-dependent inhibitor of hOAT with a k_inact/K_I of 0.219 mM^-1 min^-1^[1].
OAT-IN-2 (2-18 equiv; 72 h) irreversibly inhibits hOAT, as no enzymatic activity was recovered after 72 h of dialysis^[1].
OAT-IN-2 forms a noncovalent, tight-binding adduct with hOAT^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3057206-96-6
Molecular Weight 177.15
Formula C₇H₉F₂NO₂
SMILES

O=C([C@]12C[C@H](N)C[C@@]1([H])C2(F)F)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers^[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Devitt AN, et al. Design and Elucidation of a Strain-Relief-Driven Ring Opening Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3R,5R)-3-Amino-6,6-difluorobicyclo[3.1.0]hexane-1-carboxylic Acid. J Am Chem Soc. 2026 Aug 19;148(32):34916-34927.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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