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Omzotirome  (Synonyms: TRC-150094)

Cat. No.: HY-106425 Purity: 99.89%
COA Handling Instructions

Omzotirome (TRC150094), a functional analog of iodothyronines, can be used for the research of hyperlipidaemia (WO2008149379).

For research use only. We do not sell to patients.

Omzotirome Chemical Structure

Omzotirome Chemical Structure

CAS No. : 1092551-88-6

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Based on 1 publication(s) in Google Scholar

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Description

Omzotirome (TRC150094), a functional analog of iodothyronines, can be used for the research of hyperlipidaemia (WO2008149379)[1][2].

In Vivo

Omzotirome (0.750 mg/ 100 g; i.p.) with high-fat diet rats have significantly less visceral adipose tissue (vs. HFD rats) and exhibit altered metabolism in two major tissues that are very active metabolically and exhibit increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats[1].
Omzotirome, a functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet (HFD)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (8 weeks)[1]
Dosage: 0.750 mg/ 100 g
Administration: I.p.
Result: With high-fat diet rats had significantly less visceral adipose tissue (vs. HFD rats) and exhibited altered metabolism in two major tissues that were very active metabolically and exhibited increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats.
Clinical Trial
Molecular Weight

328.41

Formula

C19H24N2O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(CC2=C(N(CCC(O)=O)N=C2C)C)=C3C(CCC3)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (304.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0450 mL 15.2249 mL 30.4497 mL
5 mM 0.6090 mL 3.0450 mL 6.0899 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0450 mL 15.2249 mL 30.4497 mL 76.1244 mL
5 mM 0.6090 mL 3.0450 mL 6.0899 mL 15.2249 mL
10 mM 0.3045 mL 1.5225 mL 3.0450 mL 7.6124 mL
15 mM 0.2030 mL 1.0150 mL 2.0300 mL 5.0750 mL
20 mM 0.1522 mL 0.7612 mL 1.5225 mL 3.8062 mL
25 mM 0.1218 mL 0.6090 mL 1.2180 mL 3.0450 mL
30 mM 0.1015 mL 0.5075 mL 1.0150 mL 2.5375 mL
40 mM 0.0761 mL 0.3806 mL 0.7612 mL 1.9031 mL
50 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5225 mL
60 mM 0.0507 mL 0.2537 mL 0.5075 mL 1.2687 mL
80 mM 0.0381 mL 0.1903 mL 0.3806 mL 0.9516 mL
100 mM 0.0304 mL 0.1522 mL 0.3045 mL 0.7612 mL
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Omzotirome Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Omzotirome
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