2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP1/2-IN-3

PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice.

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PARP1/2-IN-3

PARP1/2-IN-3 화학구조

CAS No. : 3032451-58-1

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PARP1/2-IN-3 Related Antibodies

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제품 설명

PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice[1].

IC50 & Target

PARP-1

0.2235 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
CAPAN-1 IC50
1.82 nM
Compound: 2
Antiproliferative activity against human CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
Antiproliferative activity against human CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
[PMID: 37605459]
CAPAN-1 IC50
9.98 nM
Compound: 2
Antiproliferative activity against human Talazoparib-resistant CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
Antiproliferative activity against human Talazoparib-resistant CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
[PMID: 37605459]
분자량

484.48

화학식

C26H21FN6O3
CAS No.
SMILES

CC1=CC=C(O1)C2=NN=C3CN(CCN32)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PARP1/2-IN-3 Related Classifications

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Keywords:

PARP1/2-IN-33032451-58-1PARPpoly ADP ribose polymerasepancreatic cancerBALB/c mouseCapan-1Inhibitorinhibitorinhibit

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상품명:
PARP1/2-IN-3
Cat. No.:
HY-163817
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