PD-159206
PD-159206 is an anti-HIV agent. PD-159206 inhibits early pre-integration steps of the HIV life cycle, and delays sequential progression of reverse transcription products. PD-159206 can be used for the research of HIV infection.
For research use only. We do not sell to patients.
- CAS No.: 171744-42-6
- Formula: C26H32N2O6S2
- Molecular Weight:532.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 |
PD-159206 (5 days) inhibits replication of laboratory and clinical HIV-1 isolates, HIV-2, and SIV in H9, MT4, CEM, CEM-SS, PBMC, and macrophage cell systems[1].
PD-159206 (0.1-100 μM; 48 h) dose-dependently inhibits HIV-1 replication in HeLa-CD4-LTR-β-gal cells[1].
PD-159206 (20 μM; 48 h) inhibits early steps of the HIV-1 life cycle in HeLa-CD4-LTR-β-gal cells, with maximum effectiveness when added within the first 4 hours of infection and complete loss of activity by 6 hours post-infection[1].
PD-159206 (20 μM; 4-24 h) delays the progression of HIV-1 reverse transcription and prevents formation of 2LTR circles in H9 cells, indicating inhibition of pre-integration steps in the viral life cycle[1].
PD-159206 (0.1-100 μM; 48 h) shows no cytotoxicity up to 100 μM in HeLa Magi cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa Magi cells
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Concentration:0.1; 1; 3; 6; 12; 25; 50; 100 μM
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Incubation Time:48 h
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Result:Showed no cytotoxicity in HeLa Magi cells.
Remained cell viability above 80% at all tested concentration.
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Cell Line:H9 cells infected with HIV-III B
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Concentration:20 μM
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Incubation Time:4; 12; 24 h
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Result:Delayed the progression of HIV-1 reverse transcription and prevents formation of 2LTR circles in H9 cells.
Chemical Information
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CAS No. 171744-42-6
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Molecular Weight 532.67
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Formula C26H32N2O6S2
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SMILES
O=C(C(C(CC)C)NC(C1=C(SSC2=C(C(NC(C(CC)C)C(O)=O)=O)C=CC=C2)C=CC=C1)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sharmeen L, et al. Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374. Antiviral Res. 2001;49(2):101-114. [Content Brief]
[2]. Ye M, et al. Microdialysis sampling of the isothiazolone, PD-161374, and its thiol and disulfide metabolites. J Pharm Biomed Anal. 2000;24(2):273-280. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-159206 Related Classifications
HY-183663 Related Classifications
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