PD-159206 

PD-159206 is an anti-HIV agent. PD-159206 inhibits early pre-integration steps of the HIV life cycle, and delays sequential progression of reverse transcription products. PD-159206 can be used for the research of HIV infection^[1][2].

PD-159206 (5 days) inhibits replication of laboratory and clinical HIV-1 isolates, HIV-2, and SIV in H9, MT4, CEM, CEM-SS, PBMC, and macrophage cell systems^[1].
PD-159206 (0.1-100 μM; 48 h) dose-dependently inhibits HIV-1 replication in HeLa-CD4-LTR-β-gal cells^[1].
PD-159206 (20 μM; 48 h) inhibits early steps of the HIV-1 life cycle in HeLa-CD4-LTR-β-gal cells, with maximum effectiveness when added within the first 4 hours of infection and complete loss of activity by 6 hours post-infection^[1].
PD-159206 (20 μM; 4-24 h) delays the progression of HIV-1 reverse transcription and prevents formation of 2LTR circles in H9 cells, indicating inhibition of pre-integration steps in the viral life cycle^[1].
PD-159206 (0.1-100 μM; 48 h) shows no cytotoxicity up to 100 μM in HeLa Magi cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

532.67

C₂₆H₃₂N₂O₆S₂

171744-42-6

O=C(C(C(CC)C)NC(C1=C(SSC2=C(C(NC(C(CC)C)C(O)=O)=O)C=CC=C2)C=CC=C1)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sharmeen L, et al. Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374. Antiviral Res. 2001;49(2):101-114.  [Content Brief]

  [2]. Ye M, et al. Microdialysis sampling of the isothiazolone, PD-161374, and its thiol and disulfide metabolites. J Pharm Biomed Anal. 2000;24(2):273-280.