PD-L1-IN-3
Based on 1 Customer Validation
PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.69%
- CAS 番号: 2953044-29-4
- 分子式: C19H16ClFN2OS
- 分子量:374.86
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
PD-L1-IN-3 (Compound 4a) (0.01-100 μM, 40 min) disrupts the binding between PD-1 and PD-L1 and enhances a TCR-mediated activation of the Jurkat cells[1].
PD-L1-IN-3 (0.01-100 μM, 40 min) has higher uptake which correlated with PD-L1 expression in PD-L1+ H358 tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:0.01-100 μM
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Incubation Time:40 min
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Result:Observed EC50 value of 2.70 μM.
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Cell Line:PD-L1+/− (H358 and ES2) tumor
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Concentration:0.01-100 μM
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Incubation Time:40 min
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Result:Observed 40-55% higher uptake in PD-L1+ H358 tumors than in wild-type counterparts.
Failed to discriminate between wild-type and knock-out for ES2 slides.
体内実験
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Animal Model:PD-L1+/− (H358 and ES2) tumor[1]
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Dosage:0.01-100 μM
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Administration:incubation
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Result:Observed 40-55% higher uptake in PD-L1+ H358 tumors than in wild-type counterparts.
Failed to discriminate between wild-type and knock-out for ES2 slides.
化学情報
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CAS 番号 2953044-29-4
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性状 Solid
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分子量 374.86
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分子式 C19H16ClFN2OS
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Color White to off-white
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SMILES
FC1=CC=C(C2=CSC(OCC3=CC=C(CN)C=C3)=C2C#N)C=C1.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (333.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6677 mL | 13.3383 mL | 26.6766 mL | 66.6916 mL |
| 5 mM | 0.5335 mL | 2.6677 mL | 5.3353 mL | 13.3383 mL | |
| 10 mM | 0.2668 mL | 1.3338 mL | 2.6677 mL | 6.6692 mL | |
| 15 mM | 0.1778 mL | 0.8892 mL | 1.7784 mL | 4.4461 mL | |
| 20 mM | 0.1334 mL | 0.6669 mL | 1.3338 mL | 3.3346 mL | |
| 25 mM | 0.1067 mL | 0.5335 mL | 1.0671 mL | 2.6677 mL | |
| 30 mM | 0.0889 mL | 0.4446 mL | 0.8892 mL | 2.2231 mL | |
| 40 mM | 0.0667 mL | 0.3335 mL | 0.6669 mL | 1.6673 mL | |
| 50 mM | 0.0534 mL | 0.2668 mL | 0.5335 mL | 1.3338 mL | |
| 60 mM | 0.0445 mL | 0.2223 mL | 0.4446 mL | 1.1115 mL | |
| 80 mM | 0.0333 mL | 0.1667 mL | 0.3335 mL | 0.8336 mL | |
| 100 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6669 mL |
PD-L1-IN-3 関連分類
HY-155101 関連分類
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