PD-L1-IN-3
Based on 1 Customer Validation
PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research.
For research use only. We do not sell to patients.
- Purity: 99.69%
- CAS No.: 2953044-29-4
- Formula: C19H16ClFN2OS
- Molecular Weight:374.86
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
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Immunology/Inflammation Compound Library
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Anti-Cancer Compound Library
HY-L025
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Small Molecule Immuno-Oncology Compound Library
HY-L031
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Anti-Lung Cancer Compound Library
HY-L075
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
PD-L1-IN-3 (Compound 4a) (0.01-100 μM, 40 min) disrupts the binding between PD-1 and PD-L1 and enhances a TCR-mediated activation of the Jurkat cells[1].
PD-L1-IN-3 (0.01-100 μM, 40 min) has higher uptake which correlated with PD-L1 expression in PD-L1+ H358 tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:0.01-100 μM
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Incubation Time:40 min
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Result:Observed EC50 value of 2.70 μM.
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Cell Line:PD-L1+/− (H358 and ES2) tumor
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Concentration:0.01-100 μM
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Incubation Time:40 min
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Result:Observed 40-55% higher uptake in PD-L1+ H358 tumors than in wild-type counterparts.
Failed to discriminate between wild-type and knock-out for ES2 slides.
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Animal Model:PD-L1+/− (H358 and ES2) tumor[1]
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Dosage:0.01-100 μM
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Administration:incubation
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Result:Observed 40-55% higher uptake in PD-L1+ H358 tumors than in wild-type counterparts.
Failed to discriminate between wild-type and knock-out for ES2 slides.
Chemical Information
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CAS No. 2953044-29-4
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Appearance Solid
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Molecular Weight 374.86
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Formula C19H16ClFN2OS
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Color White to off-white
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SMILES
FC1=CC=C(C2=CSC(OCC3=CC=C(CN)C=C3)=C2C#N)C=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (333.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6677 mL | 13.3383 mL | 26.6766 mL | 66.6916 mL |
| 5 mM | 0.5335 mL | 2.6677 mL | 5.3353 mL | 13.3383 mL | |
| 10 mM | 0.2668 mL | 1.3338 mL | 2.6677 mL | 6.6692 mL | |
| 15 mM | 0.1778 mL | 0.8892 mL | 1.7784 mL | 4.4461 mL | |
| 20 mM | 0.1334 mL | 0.6669 mL | 1.3338 mL | 3.3346 mL | |
| 25 mM | 0.1067 mL | 0.5335 mL | 1.0671 mL | 2.6677 mL | |
| 30 mM | 0.0889 mL | 0.4446 mL | 0.8892 mL | 2.2231 mL | |
| 40 mM | 0.0667 mL | 0.3335 mL | 0.6669 mL | 1.6673 mL | |
| 50 mM | 0.0534 mL | 0.2668 mL | 0.5335 mL | 1.3338 mL | |
| 60 mM | 0.0445 mL | 0.2223 mL | 0.4446 mL | 1.1115 mL | |
| 80 mM | 0.0333 mL | 0.1667 mL | 0.3335 mL | 0.8336 mL | |
| 100 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6669 mL |
PD-L1-IN-3 Related Classifications
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