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Cat. No.: HY-13844

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PDK1-IN-3

PDK1-IN-3 (Compound C) is a PDK1 inhibitor, with an IC₅₀ of 34 nM.

For research use only. We do not sell to patients.

CAS No.: 853909-77-0
Formula: C₂₅H₁₅N₅
Molecular Weight:385.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PDK1-IN-3 Chemical Structure

CAS No.: 853909-77-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PDK1-IN-3 (Compound C) is a PDK1 inhibitor, with an IC₅₀ of 34 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
U-87MG ATCC	EC₅₀	416 nM Compound: 2	Antiproliferative activity against human U87MG cells Antiproliferative activity against human U87MG cells	[PMID: 18248814]
U-87MG ATCC	IC₅₀	94 nM Compound: 2	Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISA Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISA	[PMID: 18248814]

Chemical Information

CAS No. 853909-77-0
Molecular Weight 385.42
Formula C₂₅H₁₅N₅
SMILES

N#CCC(C=C1)=CC=C1N2C=NC3=C2C4=CC(C#CC5=CC=CN=C5)=CC=C4N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Murphy ST, et al. Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1). J Med Chem. 2011 Dec 22;54(24):8490-500. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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