PF-8380 (Standard)
PF-8380 (Standard) is the analytical standard of PF-8380. This product is intended for research and analytical applications. PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98%
- No. CAS: 1144035-53-9
- Fòrmula: C22H21Cl2N3O5
- Peso molecular:478.33
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Pureza y Documentación
-
Help & FAQs
-
HY-13344
PF-8380Autotaxin Inhibitor -
HY-19329
HA130Autotaxin Inhibitor -
HY-16900
RolipramPDE4 Inhibitor -
HY-15455
RoflumilastPDE4 Inhibitor -
HY-B0312
DipyridamolePDE Inhibitor -
HY-14252
Milrinone -
HY-90009A
TadalafilPDE5 Inhibitor -
HY-12085
ApremilastPDE-4 Inhibitor -
HY-101772
ZiritaxestatAutotaxin Inhibitor -
HY-N0162
LuteolinNrf2 Inhibitor -
HY-10978
CrisaborolePDE Inhibitor -
HY-B0442
VardenafilPDE5 Inhibitor
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
No. CAS 1144035-53-9
-
Peso molecular 478.33
-
Fòrmula C22H21Cl2N3O5
-
SMILES
O=C(N1CCN(CC1)CCC(C2=CC(O3)=C(C=C2)NC3=O)=O)OCC4=CC(Cl)=CC(Cl)=C4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Gierse J, et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther. 2010 Jul;334(1):310-7. [Content Brief]
[2]. Bhave SR, et al. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013 Sep 17;3:236. [Content Brief]
[3]. Cao P, et al. Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis. J Clin Invest. 2017 Apr 3;127(4):1517-1530. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-8380 (Standard) Related Classifications
HY-13344R Related Classifications
Powered by Bioz