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Cat. No.: HY-133908

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PFI-3 Control

PFI-3 Control is an inactive analog of PFI-3 (HY-12409), serving as an inactive negative control. PFI-3 Control shows no detectable binding activity toward purified PB1 (5), SMARCA2A, SMARCA2B, and SMARCA4 family VIII bromodomain proteins.

For research use only. We do not sell to patients.

CAS No.: 1914047-60-1
Formula: C₂₂H₂₃N₅O₃
Molecular Weight:405.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PFI-3 Control Chemical Structure

CAS No.: 1914047-60-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Help & FAQs
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Bioz

Biological Activity

Description

All SWI/SNF Complex Isoforms :

In Vitro

PFI-3 Control (Compound 18) (100 nM-1 μM) fails to displace GFP-tagged PB1 from chromatin in SAHA (HY-10221)-treated U2OS cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1914047-60-1
Molecular Weight 405.45
Formula C₂₂H₂₃N₅O₃
SMILES

O=C(C1=CC=CC(OC)=C1O)/C=C/N2[C@@](C3)([H])CN(C4=NC=CC(NCC#C)=N4)[C@@]3([H])C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gerstenberger BS, et al. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit. Journal of medicinal chemistry. 2016 May 26;59(10):4800-11. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PFI-3 Control

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PFI-3 Control Related Classifications

HY-133908 Related Classifications