2. NF-κB
  3. IKK
  4. PHA 408

PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation.

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PHA 408

PHA 408 화학구조

CAS No. : 503555-55-3

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

PHA 408 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PHA 408

View All IKK Isoform Specific Products:

View All Isoforms
IKK-α IKK-β IKK IKKε TBK1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].

IC50 & Target

IKK-2

 

Cellular Effect
Cell Line Type Value Description References
PBMC IC50
39 nM
Compound: PHA-408
Inhibition of LPS-stimulated TNFalpha release in human PBMC
Inhibition of LPS-stimulated TNFalpha release in human PBMC
[PMID: 21236687]
분자량

560.02

화학식

C29H27ClFN7O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 50 mg/mL (89.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7857 mL 8.9283 mL 17.8565 mL
5 mM 0.3571 mL 1.7857 mL 3.5713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.40%

SDS (393 KB)

COA (249 KB) HNMR (308 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7857 mL 8.9283 mL 17.8565 mL 44.6413 mL
5 mM 0.3571 mL 1.7857 mL 3.5713 mL 8.9283 mL
10 mM 0.1786 mL 0.8928 mL 1.7857 mL 4.4641 mL
15 mM 0.1190 mL 0.5952 mL 1.1904 mL 2.9761 mL
20 mM 0.0893 mL 0.4464 mL 0.8928 mL 2.2321 mL
25 mM 0.0714 mL 0.3571 mL 0.7143 mL 1.7857 mL
30 mM 0.0595 mL 0.2976 mL 0.5952 mL 1.4880 mL
40 mM 0.0446 mL 0.2232 mL 0.4464 mL 1.1160 mL
50 mM 0.0357 mL 0.1786 mL 0.3571 mL 0.8928 mL
60 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7440 mL
80 mM 0.0223 mL 0.1116 mL 0.2232 mL 0.5580 mL
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PHA 408 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHA 408503555-55-3PHA408PHA-408IKKIκB kinaseI kappa B kinaseselectiveorally activeanti-inflammatory agentlipopolysaccharidecigarette smokeInhibitorinhibitorinhibit

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Inquiry Information

상품명:
PHA 408
Cat. No.:
HY-14180
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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