country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183198

Copy Link Print Information

PIM-IN-5

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 2139294-71-4
Formula: C₁₆H₁₈Cl₂N₄O
Molecular Weight:353.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIM-IN-5 Chemical Structure

CAS No.: 2139294-71-4

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia^[1].

All Pim Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KG-1	IC₅₀	62 nM Compound: (S)-11	Antiproliferative activity against human KG1 cells Antiproliferative activity against human KG1 cells	[PMID: 28927793]

In Vitro

PIM-IN-5 (Compound 1) inhibits KG1 cell viability with an EC₅₀ of 43 nM^[1].
PIM-IN-5 inhibits pS6 in KG1 cells with an EC₅₀ of 62 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2139294-71-4
Molecular Weight 353.25
Formula C₁₆H₁₈Cl₂N₄O
SMILES

ClC1=C(C2CC2)N([C@H]3CCCNC3)C4=NC(C(N)=O)=CC(Cl)=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Barberis C, et al. Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III. Bioorg Med Chem Lett. 2019;29(3):491-495. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PIM-IN-5

All Pim Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PIM-IN-5 Related Classifications

HY-183198 Related Classifications