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Referencia número: HY-183198

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PIM-IN-5

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2139294-71-4
Fòrmula: C₁₆H₁₈Cl₂N₄O
Peso molecular:353.25

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIM-IN-5 Chemical Structure

No. CAS: 2139294-71-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia^[1].

Ver todos los productos específicos de isoformas Pim :

Cellular Effect

Cell Line	Type	Value	Description	References
KG-1	IC₅₀	62 nM Compound: (S)-11	Antiproliferative activity against human KG1 cells Antiproliferative activity against human KG1 cells	[PMID: 28927793]

In Vitro

PIM-IN-5 (Compound 1) inhibits KG1 cell viability with an EC₅₀ of 43 nM^[1].
PIM-IN-5 inhibits pS6 in KG1 cells with an EC₅₀ of 62 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

No. CAS 2139294-71-4
Peso molecular 353.25
Fòrmula C₁₆H₁₈Cl₂N₄O
SMILES

ClC1=C(C2CC2)N([C@H]3CCCNC3)C4=NC(C(N)=O)=CC(Cl)=C41
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Barberis C, et al. Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III. Bioorg Med Chem Lett. 2019;29(3):491-495. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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