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Cat. No.: HY-184933

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PIN1-IN-8

PIN1-IN-8 (Compound T41) is a covalent inhibitor of Pin1, with IC₅₀ values of 0.13 μM and 0.02 μM against purified Pin1 and Pin1 enzymatic activity, respectively. PIN1-IN-8 can be used in triple-negative breast cancer research.

For research use only. We do not sell to patients.

Formula: C₁₅H₁₇NO₅S
Molecular Weight:323.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIN1-IN-8 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 323.36
Formula C₁₅H₁₇NO₅S
SMILES

O=C(NC1CS(CC1)(=O)=O)/C=C\C(OCC2=CC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tian M, et al. Structure-Based Discovery of (E)- and (Z)-4-Oxobut-2-enoate Derivatives as Novel Covalent Pin1 Inhibitors with Antitumor Activity. J Med Chem. 2026 Jul 2.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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