2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPARα agonist 2

PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research.

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PPARα agonist 2

PPARα agonist 2 Chemical Structure

CAS No. : 2376590-40-6

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PPARα agonist 2 Related Antibodies

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Description

PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research[1].

IC50 & Target[1]

PPARα

37 nM (EC50)

Molecular Weight

365.40

Formula

C22H20FNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=CC(NCC2=CC=C(OCC3=CC=C(F)C=C3)C(C)=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 20 mg/mL (54.73 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7367 mL 13.6836 mL 27.3673 mL
5 mM 0.5473 mL 2.7367 mL 5.4735 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.9%

SDS (252 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.7367 mL 13.6836 mL 27.3673 mL 68.4182 mL
5 mM 0.5473 mL 2.7367 mL 5.4735 mL 13.6836 mL
10 mM 0.2737 mL 1.3684 mL 2.7367 mL 6.8418 mL
15 mM 0.1824 mL 0.9122 mL 1.8245 mL 4.5612 mL
20 mM 0.1368 mL 0.6842 mL 1.3684 mL 3.4209 mL
25 mM 0.1095 mL 0.5473 mL 1.0947 mL 2.7367 mL
30 mM 0.0912 mL 0.4561 mL 0.9122 mL 2.2806 mL
40 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7105 mL
50 mM 0.0547 mL 0.2737 mL 0.5473 mL 1.3684 mL
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PPARα agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARα agonist 22376590-40-6PPARα agonist2PPARα agonist-2PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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