PPARα/γ agonist 4
PPARα/γ agonist 4 (Compound (S)-7) is an orally active dual potent agonist of PPARα and PPARγ, with EC50 values of 0.061 μM and 1.42 μM respectively. PPARα/γ agonist 4 acts through an insulin-independent mechanism and exhibits mitochondrial pyruvate carrier inhibition and anti-diabetic properties. PPARα/γ agonist 4 is expected to be used in research for dyslipidemic type 2 diabetes.
For research use only. We do not sell to patients.
- Formula: C25H20O3
- Molecular Weight:368.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PPARα |
PPAR-γ |
PPARα/γ agonist 4 (100 nM, 24 h) is able to increase the uptake and metabolism of glucose in C2C12 cell line and enhance mitochondrial activity by boosting fatty acid degradation, thus avoiding lipid accumulation in liver or muscle cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis in MC38 Syngeneic Model[1]
| PPARα/γ agonist 4 | Does Volume (mL/kg) | C0/Cmax(ng/mL) | Tmax (h) | AUClast(h·ng/mL) | AUCinfinity (h⋅ng/mL) | T1/2 (h) | Vd (L/kg) | CL (mL/min/kg) | MRTlast(h) | F (%) |
| i.v. (1 mg/kg) | 10 | 2300 | 0.083 | 11400 | 11800 | 4.74 | 0.581 | 1.42 | 6.04 | - |
| p.o. (5 mg/kg) | 10 | 4280 | 2 | 43600 | 49000 | 7.61 | 1.16 | 1.74 | 7.74 | 76.4 |