1. PROTAC
  2. PROTAC Linkers
  3. Propargyl-PEG2-NHS ester

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Propargyl-PEG2-NHS ester Chemical Structure

Propargyl-PEG2-NHS ester Chemical Structure

CAS No. : 2512228-06-5

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Description

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

269.25

Formula

C12H15NO6

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCCOCC#C)ON1C(CCC1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (928.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7140 mL 18.5701 mL 37.1402 mL
5 mM 0.7428 mL 3.7140 mL 7.4280 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7140 mL 18.5701 mL 37.1402 mL 92.8505 mL
5 mM 0.7428 mL 3.7140 mL 7.4280 mL 18.5701 mL
10 mM 0.3714 mL 1.8570 mL 3.7140 mL 9.2851 mL
15 mM 0.2476 mL 1.2380 mL 2.4760 mL 6.1900 mL
20 mM 0.1857 mL 0.9285 mL 1.8570 mL 4.6425 mL
25 mM 0.1486 mL 0.7428 mL 1.4856 mL 3.7140 mL
30 mM 0.1238 mL 0.6190 mL 1.2380 mL 3.0950 mL
40 mM 0.0929 mL 0.4643 mL 0.9285 mL 2.3213 mL
50 mM 0.0743 mL 0.3714 mL 0.7428 mL 1.8570 mL
60 mM 0.0619 mL 0.3095 mL 0.6190 mL 1.5475 mL
80 mM 0.0464 mL 0.2321 mL 0.4643 mL 1.1606 mL
100 mM 0.0371 mL 0.1857 mL 0.3714 mL 0.9285 mL
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Propargyl-PEG2-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Propargyl-PEG2-NHS ester
Cat. No.:
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