2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG4-amine

Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG4-amine Chemical Structure

Propargyl-PEG4-amine Chemical Structure

CAS No. : 1013921-36-2

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25 mg USD 40 In-stock
50 mg USD 60 In-stock
100 mg USD 90 In-stock
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Based on 1 publication(s) in Google Scholar

Propargyl-PEG4-amine Related Antibodies

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Description

Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG4-amine Related Antibodies
Molecular Weight

231.29

Formula

C11H21NO4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (216.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3236 mL 21.6179 mL 43.2358 mL
5 mM 0.8647 mL 4.3236 mL 8.6472 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.71%

COA (239 KB) HNMR (117 KB) GC (211 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3236 mL 21.6179 mL 43.2358 mL 108.0894 mL
5 mM 0.8647 mL 4.3236 mL 8.6472 mL 21.6179 mL
10 mM 0.4324 mL 2.1618 mL 4.3236 mL 10.8089 mL
15 mM 0.2882 mL 1.4412 mL 2.8824 mL 7.2060 mL
20 mM 0.2162 mL 1.0809 mL 2.1618 mL 5.4045 mL
25 mM 0.1729 mL 0.8647 mL 1.7294 mL 4.3236 mL
30 mM 0.1441 mL 0.7206 mL 1.4412 mL 3.6030 mL
40 mM 0.1081 mL 0.5404 mL 1.0809 mL 2.7022 mL
50 mM 0.0865 mL 0.4324 mL 0.8647 mL 2.1618 mL
60 mM 0.0721 mL 0.3603 mL 0.7206 mL 1.8015 mL
80 mM 0.0540 mL 0.2702 mL 0.5404 mL 1.3511 mL
100 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0809 mL
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Propargyl-PEG4-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG4-amine1013921-36-2PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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