Propargyl-PEG6-NH2

Name: Propargyl-PEG6-NH2
Brand: MedChemExpress
SKU: HY-130180
Rating: 4.5 (1 reviews)

Cat. No.: HY-130180 Purity: 99.69%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG6-NH2 Chemical Structure

CAS No. : 1198080-04-4

Size	Price	Stock	Quantity
50 mg	USD 68	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 185	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs^[1]. Propargyl-PEG6-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

319.39

Formula

C₁₅H₂₉NO₆

CAS No.

1198080-04-4

Appearance

Liquid

Color

Colorless to light yellow

SMILES

C#CCOCCOCCOCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (782.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1310 mL	15.6548 mL	31.3097 mL
5 mM	0.6262 mL	3.1310 mL	6.2619 mL
10 mM	0.3131 mL	1.5655 mL	3.1310 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (265 KB) SDS (393 KB)

COA (238 KB) RP-HPLC (214 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1310 mL	15.6548 mL	31.3097 mL	78.2742 mL
	5 mM	0.6262 mL	3.1310 mL	6.2619 mL	15.6548 mL
	10 mM	0.3131 mL	1.5655 mL	3.1310 mL	7.8274 mL
	15 mM	0.2087 mL	1.0437 mL	2.0873 mL	5.2183 mL
	20 mM	0.1565 mL	0.7827 mL	1.5655 mL	3.9137 mL
	25 mM	0.1252 mL	0.6262 mL	1.2524 mL	3.1310 mL
	30 mM	0.1044 mL	0.5218 mL	1.0437 mL	2.6091 mL
	40 mM	0.0783 mL	0.3914 mL	0.7827 mL	1.9569 mL
	50 mM	0.0626 mL	0.3131 mL	0.6262 mL	1.5655 mL
	60 mM	0.0522 mL	0.2609 mL	0.5218 mL	1.3046 mL
	80 mM	0.0391 mL	0.1957 mL	0.3914 mL	0.9784 mL
	100 mM	0.0313 mL	0.1565 mL	0.3131 mL	0.7827 mL