1. PROTAC
    Others
  2. SNIPER
    PROTAC
    Androgen Receptor
  3. PROTAC AR Degrader-4 TFA

PROTAC AR Degrader-4 TFA 

Cat. No.: HY-111848A Purity: ≥98.0%
Handling Instructions

PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

For research use only. We do not sell to patients.

PROTAC AR Degrader-4 TFA Chemical Structure

PROTAC AR Degrader-4 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PROTAC AR Degrader-4 TFA:

Top Publications Citing Use of Products

View All PROTAC Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

IC50 & Target[1]

cIAP1

 

In Vitro

Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure.
Targeting proteins for degradation involves three steps.
1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein.
2, the target protein is polyubiquitinated by IAPs.
3, the polyubiquitinated protein is degraded by proteasome.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

884.03

Formula

C₄₅H₆₈F₃N₃O₁₁

SMILES

O=C1CC[[email protected]@]2(C)[[email protected]](CC[[email protected]]3([H])[[email protected]]2([H])CC[[email protected]@]4(C)[[email protected]@]3([H])CC[[email protected]@H]4OC(COCCOCCOCCNC([[email protected]](CC(C)C)NC([[email protected]@H](O)[[email protected]](N)CC5=CC=CC=C5)=O)=O)=O)([H])C1.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-80°C

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (226.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1312 mL 5.6559 mL 11.3118 mL
5 mM 0.2262 mL 1.1312 mL 2.2624 mL
10 mM 0.1131 mL 0.5656 mL 1.1312 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (5.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (5.66 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC AR Degrader-4PROTAC AR Degrader4PROTAC AR Degrader 4SNIPERPROTACAndrogen ReceptorIAP-dependent Protein Eraser, Specific and Nongenetic inhibitor of apoptosis protein [IAP]-dependent Protein EraserProteolysis-targeting chimeraInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PROTAC AR Degrader-4 TFA
Cat. No.:
HY-111848A
Quantity:
MCE Japan Authorized Agent: