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Cat. No.: HY-182910

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PROTAC BTK Degrader-15

PROTAC BTK Degrader-15 is a heterobifunctional molecule and PBLEC 4 that catalyzes degradation of BTK. PROTAC BTK Degrader-15 can be used for the research of b-cell blood cancers.
(Pink: Btk ligand (HY-182933); Blue: Cereblon ligand (HY-182911); Black: linker).

For research use only. We do not sell to patients.

Formula: C₄₄H₅₀N₁₀O₄
Molecular Weight:782.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC BTK Degrader-15 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

PROTAC BTK Degrader-15 is a heterobifunctional molecule and PBLEC 4 that catalyzes degradation of BTK. PROTAC BTK Degrader-15 can be used for the research of b-cell blood cancers^[1]. (Pink: Btk ligand (HY-182933); Blue: Cereblon ligand (HY-182911); Black: linker).

IC₅₀ & Target^[1]

BTK

All PROTACs Isoforms :

Chemical Information

Molecular Weight 782.93
Formula C₄₄H₅₀N₁₀O₄
SMILES

O=C(C1=NC(C(C)(C)C)=NO1)N[C@H](C)C(C=C2)=C(C)C=C2C3=NC(NC4=CC=C(CCN5CCC(C6=CC=C(NC78C(NC(C(C8)C7)=O)=O)C=C6)CC5)C=C4)=NC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Haibach MC, Klix R, Pullela S, et al. Early Process Development of a Heterobifunctional Protein Degrader. Organic Process Research & Development. 2026 Mar 30;30(4):892‑899.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PROTAC BTK Degrader-15

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BTK Degrader-15 Related Classifications

HY-182910 Related Classifications