PROTAC EGFR degrader 12
PROTAC EGFR degrader 12 (example 1) is a PROTAC degrader targeting EGFR that can effectively degrade EGFR mutants, but has little effect on EGFR WT. PROTAC EGFR degrader 12 shows IC50s against EGFRL858R-T790M (NCI-H1975 cells), EGFRL858R (NCI-H3255 cells), and EGFRL858R-T790M-L797S (NCI-H1975+CS cells) of all <50 nM.
For research use only. We do not sell to patients.
- CAS No.: 2654821-05-1
- Formula: C48H48F2N10O6S
- Molecular Weight:931.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTAC EGFR degrader 12 (example 1) showed growth inhibition against Ba/F3 cell lines expressing EGFR WT and mutant, with CTG50 of 1.62 μM (EGFR WT) and 5-21 nM (EGFR mutant), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2654821-05-1
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Molecular Weight 931.02
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Formula C48H48F2N10O6S
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SMILES
OC1(CCN(C2=C(C=C(C=C2)N[C@@H]3C(NC(CC3)=O)=O)F)CC1)CC(N4CC5(C4)CN(C6=CC=C(C7=CC(F)=C(CN(C8=O)C(C9=C%10N(CCC%10)C=N9)C(NC%11=NC=CS%11)=O)C8=C7)C=C6)C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC EGFR degrader 12 Related Classifications
HY-171958 Related Classifications
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