ERK2/MAPK1
ERK2 (MAPK1) is the 42 kDa workhorse of the classical MAP kinase cascade and the more abundant of the ERK pair. Activated by MEK1/2-mediated phosphorylation of Thr185 and Tyr187 within its TEY motif, it signals through docking-site interactions with substrates and regulators, phosphorylating transcription factors such as Elk-1 and c-Fos, kinases such as RSK and MNK, and cytoplasmic targets that control proliferation, differentiation, and survival. ERK2 is essential for embryonic development, and its pathway is constitutively activated by RAS and RAF mutations in a large fraction of cancers. Recombinant ERK2 is widely used for kinase assays, substrate screening, and ERK-pathway inhibitor characterization.
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ERK2/MAPK1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
