Integrin alpha L beta 2
Integrin alpha L beta 2 is the molecular designation of LFA-1, the CD11a/CD18 heterodimer of the beta-2 family. This entry emphasizes its conformational regulation and signaling: the alpha L I-domain exists in closed, intermediate and open states, coupled through the beta-propeller and hybrid domain to a global bent-to-extended transition. Chemokine inside-out signaling via Rap1, talin-1 and kindlin-3 locks the open conformation, while ligand binding to ICAMs triggers outside-in signals through Src family kinases and adaptor proteins that reinforce adhesion and cytoskeletal remodeling. Alpha L beta 2 is required for T cell transendothelial migration and immunological synapse formation, and its absence causes leukocyte adhesion deficiency type 1.
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Integrin alpha L beta 2 Protéines Recombinantes (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
