PRKACA/PKAc alpha
Encoded by the PRKACA gene, the alpha isoform of the cAMP-dependent protein kinase (PKA) catalytic subunit is the predominant C subunit in most tissues. In the resting holoenzyme it is held inactive by regulatory subunits; cAMP binding releases the catalytic subunit to phosphorylate serine/threonine residues in RRX(S/T) motifs on targets such as CREB, ion channels and metabolic enzymes. PKA Ca underpins hormone-stimulated glycogen breakdown, lipolysis and steroidogenesis and controls proliferation through CREB-driven transcription. Somatic PRKACA alterations cause cortisol-producing adenomas in Cushing syndrome, and a DNAJB1-PRKACA fusion drives fibrolamellar hepatocellular carcinoma, making the alpha subunit a clinically validated marker.
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PRKACA/PKAc alpha Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
