PRKG1/PKG1
PRKG1 encodes cGMP-dependent protein kinase 1, the principal effector of nitric oxide-cGMP signaling in smooth muscle and platelets. Alternative promoter usage and splicing generate the PKG1alpha and PKG1beta isoforms, which share a cGMP-binding regulatory region and a serine/threonine kinase domain but differ at their N-termini. cGMP binding activates PKG1 to phosphorylate targets that lower cytosolic calcium, producing vasodilation, inhibition of smooth-muscle proliferation and suppression of platelet aggregation. PRKG1 variants have been associated with aortic disease phenotypes. Recombinant PKG1 is a standard tool for studying vascular relaxation mechanisms and for evaluating compounds acting through the NO-sGC-cGMP axis.
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PRKG1/PKG1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
