PSB-24379
PSB-24379 is a CD39 inhibitor that potently inhibits human membrane-bound CD39 (Ki = 77.4 nM) and truncated soluble human CD39 (Ki = 23.1 nM). PSB-24379 reduces the level of ATP hydrolysis in melanoma and breast cancer cell membranes. PSB-24379 partially reverses ATP-mediated suppression of T cell activation and proliferation in a high-ATP environment. PSB-24379 can be used in research related to melanoma and breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C30H32N5O7PS
- 分子量:637.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
PSB-24379 potently inhibits both human membrane-bound CD39 (Ki = 77.4 nM) and truncated soluble human CD39 (Ki = 23.1 nM)[1].
PSB-24379 inhibits human CD73 with a Ki of 240 nM[1].
PSB-24379 reduces ATP hydrolysis activity in membrane preparations from human Ma-Mel-65 melanoma cells and human MDA-MB-231 triple-negative breast cancer cells[1].
PSB-24379 partially reverts ATP-mediated suppression of T cell activation in primary human peripheral blood mononuclear cells in an ATP-rich environment[1].
PSB-24379 exhibits high metabolic stability in human and mouse liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 637.64
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分子式 C30H32N5O7PS
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCCCCC4=CC=CC=C4)=C3N=C2SC5=C(C=CC=C6)C6=CC=C5)O[C@@H]1COP(O)(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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