Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities

  • J Antibiot (Tokyo). 2000 Oct;53(10):1130-6. doi: 10.7164/antibiotics.53.1130.
K Nakae  1 ,  Y Yoshimoto ,  T Sawa ,  Y Homma ,  M Hamada ,  T Takeuchi ,  M Imoto
Affiliations
  • 1. Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
PMID: 11132958 DOI: 10.7164/antibiotics.53.1130
Abstract

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered Macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal Cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.

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